Elucidation of tumor-associated macrophage accumulation mechanism accompanying tumor cell death

阐明肿瘤相关巨噬细胞伴随肿瘤细胞死亡的积累机制

• 批准号: 23701078
• 负责人: NISHITAI Gen
• 金额: $ 2.75万
• 依托单位: Tokyo University of Pharmacy and Life Science
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23701078/
• 关键词: 細胞免疫; マクロファージ

Malignant tumors arise even in an immunocompetent host by outmaneuvering immune recognition. Accumulating evidence has suggested that tumor-associated macrophages (TAMs) play a key role in tumor growth. In the previous study, we revealed that TAMs were infiltrated to tumors in response to tumor cell death. To block the protumor function of TAMs, we established anti-S100A9 monoclonal antibody and revealed that tumor growth was suppressed by administrating anti-S100A9 monoclonal antibody

恶性肿瘤即使在免疫功能正常的宿主中也会通过避开免疫识别而出现。越来越多的证据表明，肿瘤相关巨噬细胞（tam）在肿瘤生长中起着关键作用。在之前的研究中，我们发现tam在肿瘤细胞死亡时浸润到肿瘤中。为了阻断tam的肿瘤功能，我们建立了抗s100a9单克隆抗体，发现抗s100a9单克隆抗体可抑制肿瘤生长