The role of matrix metalloproteinase in cadmium-induced cancer

基质金属蛋白酶在镉诱发癌症中的作用

• 批准号: 21790560
• 负责人: NISHITAI Gen
• 金额: $ 2.75万
• 依托单位: The Institute of Physical and Chemical Research
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2009
• 资助国家: 日本
• 起止时间: 2009 至 2010
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-21790560/
• 关键词: 衛生; 癌; 細胞・組織; シグナル伝達; 免疫学

Cadmium has been classified as a human carcinogen by the International Agency for Research on Cancer. However, the molecular link between cadmium exposure and carcinogenesis is unclear. In this study, we found that matrix metalloproteinase (MMP) 9 and MMP13 were accumulated in mouse embryonic stem (ES) cells treated with CdCl_2. MMPs contribute to many steps in the carcinogenic process, including angiogenesis and metastasis. Cadmium-induced MMP9 and MMP13 expression was abolished in ES cells deficient in the activation of JNK, a member of the mitogen-activated protein kinases, suggesting that cadmium-induced MMP expression is mediated by JNK signaling pathway.

镉已被国际癌症研究机构列为人类致癌物。然而，镉暴露与致癌之间的分子联系尚不清楚。本研究发现，CdCl_2作用下小鼠胚胎干细胞中基质金属蛋白酶（MMP） 9和MMP13均有积累。MMPs参与了致癌过程的许多步骤，包括血管生成和转移。在缺乏丝裂原活化蛋白激酶成员JNK活化的ES细胞中，镉诱导的MMP9和MMP13表达被消除，这表明镉诱导的MMP表达是通过JNK信号通路介导的。

项目成果

NaF Activates MAPKs and Induces Apoptosis in Odontoblast-like Cells

• DOI: 10.1177/0022034509334771
• 发表时间: 2009-05-01
• 期刊: JOURNAL OF DENTAL RESEARCH
• 影响因子: 7.6
• 作者: Karube, H.;Nishitai, G.;Matsuoka, M.
• 通讯作者: Matsuoka, M.

HSP110 expression is induced by cadmium exposure but is dispensable for cell survival of mouse NIH3T3 fibroblasts.

HSP110 表达是由镉暴露诱导的，但对于小鼠 NIH3T3 成纤维细胞的细胞存活来说是可有可无的。

• 发表时间: 2010
• 期刊: Environmental Toxicology and Pharmacology
• 影响因子: 4.3
• 作者: 鍋山亜実;リッドレイ和佳子
• 通讯作者: リッドレイ和佳子