Electrophysiological recording using Spatially Arranged Microelectrode Embedded into 3D Culture

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3D cultures are more likely to mimic physiological tissue environments. This research focuses on spatialextracellular recordings inside 3D cultures using spatially arranged microelectrode embedded into 3Dcultures. Wire?bonding?based probe technology makes it possible to provide the 3D microelectrodes.We demonstrated electrophysiological activities inside 3D neuronal cultures could be successfullyrecorded using the embedded microelectrodes. We also indicated that cell manipulation, optical sensingand electrochemical sensing were integrated with the spatially arranged microelectrode.