Development of high-throughput measurement techniques of pharmacokinetics using stigmatic imaging mass spectrometry

使用斑头成像质谱法开发药代动力学高通量测量技术

• 批准号: 23710271
• 负责人: HAZAMA Hisanao
• 金额: $ 2.91万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2011
• 资助国家: 日本
• 起止时间: 2011 至 2012
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23710271/
• 关键词: 分子イメージング; 薬物動態; イメージング質量分析; 投影型; マトリックス支援レーザー脱離イオン化

Technical developments were performed for high-throughput measurement of pharmacokinetics using stigmatic imaging mass spectrometry withmatrix-assisted laser desorption/ionization. Optimum ionization conditions for the drug were investigated, and a sample translation device operating under high vacuum was developed. The spatial distribution of the drug in a brain of a mouse was successfully observed by using the investigated ionization conditions and the improved mass spectrometer.

利用基质辅助激光解吸/电离的色散成像质谱仪进行了高通量药代动力学测量的技术开发。研究了该药物的最佳电离条件，并研制了高真空下的样品平移装置。利用所研究的电离条件和改进的质谱计，成功地观察了药物在小鼠脑内的空间分布。

项目成果

Development of a stigmatic mass microscope for high-throughput molecular imaging

开发用于高通量分子成像的柱头质量显微镜

• 发表时间: 2012
• 期刊: Proceedings of Conference on Laser Surgery and Medicine 2012
• 作者: Hisanao Hazama;Tomonori Hamanaka;and Kunio Awazu
• 通讯作者: and Kunio Awazu

Tissue imaging with a stigmatic mass microscope using laser desorption/ionization

使用激光解吸/电离的斑块显微镜进行组织成像

• DOI: 10.1117/12.909898
• 发表时间: 2012
• 期刊: Proceedings of SPIE
• 作者: Kunio Awazu;Hisanao Hazama;Tomonori Hamanaka;Jun Aoki;Michisato Toyoda;and Yasuhide Naito
• 通讯作者: and Yasuhide Naito

Effect of solvent on ionization efficiency in matrix-assisted laser desorption/ionization mass spectrometry of peptides

• DOI: 10.1016/j.chemphys.2013.03.004
• 发表时间: 2013-06-20
• 期刊: CHEMICAL PHYSICS
• 影响因子: 2.3
• 作者: Hazama, Hisanao;Furukawa, Satoshi;Awazu, Kunio
• 通讯作者: Awazu, Kunio

Imaging mass spectrometry of pharmaceutical drugs using a high mass resolution MALDI-SpiralTOF-TOF

使用高分辨率 MALDI-SpiralTOF-TOF 对药物进行成像质谱分析

• 发表时间: 2013
• 作者: Ayumi Kubo;Takaya Satoh;Robert A. DiPasquale;Naoki Moriguchi;Hisanao Hazama;Kunio Awazu;and Michisato Toyoda
• 通讯作者: and Michisato Toyoda

Imaging mass spectrometry and structural analysis of lipids directly on tissue specimens using a high resolution MALDI-TOF-TOF tandem mass spectrometer

使用高分辨率 MALDI-TOF-TOF 串联质谱仪直接对组织样本进行成像质谱分析和脂质结构分析

• 发表时间: 2012
• 作者: Shuichi Shimma;Ayumi Kubo;Takaya Satoh;Hisanao Hazama;Kunio Awazu;and Michisato Toyoda
• 通讯作者: and Michisato Toyoda