The association between sleepiness and cognitive dysfunction and brain micro-morphological change in obstructive sleep apnea syndrome

阻塞性睡眠呼吸暂停综合征嗜睡与认知功能障碍及脑微形态变化的关系

• 批准号: 23791374
• 负责人: NAKAMURA Masaki
• 金额: $ 2.66万
• 依托单位: Neuropsychiatric Research Institute
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012 至 无数据
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-23791374/
• 关键词: 精神生理学; 重度閉塞性睡眠時無呼吸症候群; voxel-based morphometory; diffusion tensor imaging; 間欠的低酸素状態; 高次脳機能障害; 閉塞性睡眠時無呼吸症候群; 視覚性抹消課題; 数字符号照合検査; 記憶更新検査; 位置ストループ課題; MRI

We measured cognitive and emotional impairment of the patients suffered severe obstructive sleep apnea syndrome(sOSAS), and investigated the correlation between these cognitive and emotional impairment and respiratory index during sleep. Additionally, we applied the voxel-based statistic approach by SPM8-regression for FA/ADC maps and gray/white matter images to estimate the correlation between brain microstructural changes of sOSAS and respiratory index during sleep. As a results, subjective daytime sleepiness was only associated with motivation and only lowest SpO2 affected on cognitive impairment. In imaging study, lowest SpO2 showed positive correlation with medial and inferior frontal area where are important for higher cognitive function and brain-stem containing many nuclei for arousal maintaining function in FA/ADC maps and white matter image. The gray matter concentration in parahippocampal area was also affected positive correlation with lowest SpO2. As a conclusion, lower SpO2 (hypoxia invasion) might cause the cognitive impairment and this impairment would be caused by neural axonal microstructural changes by hypoxia invasion.

对重度阻塞性睡眠呼吸暂停综合征（sOSAS）患者的认知和情绪障碍进行检测，并探讨其与睡眠呼吸指标的相关性。此外，我们应用基于体素的统计方法，通过SPM 8-回归的FA/ADC图和灰色/白色物质图像来估计睡眠期间sOSAS的脑微结构变化与呼吸指数之间的相关性。因此，主观白天嗜睡只与动机相关，只有最低的SpO 2影响认知障碍。影像学研究中，最低SpO 2与FA/ADC图和白色像中对较高认知功能起重要作用的额内侧区和额下区以及含有许多维持觉醒功能核团的脑干呈正相关。海马旁区灰质浓度与最低SpO 2呈正相关。结论：低氧入侵引起的低SpO 2可能是认知功能损害的原因，低氧入侵引起的神经轴突微结构改变可能是认知功能损害的主要原因。

项目成果

重度閉塞性睡眠時無呼吸症候群の注意・意欲障害

与严重阻塞性睡眠呼吸暂停综合征相关的注意力和动机障碍

• 发表时间: 2012
• 作者: Tamaki;Y.;Arai;T.;Sugimura;H.;Sasaki;T.;Honda;M.;Muroi;Y.;Matsubara;Y.;Kanno;S.;Ishikawa;M.;Hirasawa;N.;Hiratsuka;M.;中村真樹
• 通讯作者: 中村真樹