A novel therapeutic strategy for atherosclerotic diseases by regulating developmental gene expression in perivascular adipose tissue
A novel therapeutic strategy for atherosclerotic diseases by regulating developmental gene expression in perivascular adipose tissue
批准号:
24591120
负责人:
YAMADA Hiroyuki
金额:
$3.41万
依托单位国家:
日本
项目类别:
Grant-in-Aid for Scientific Research (C)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2015-03-31
中文摘要
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Periaortic adipose tissue-specific activation of renin angiotensin system along with the adipocytes differentiation contributes to atherosclerosis in apoE-/- mice.
主动脉周围脂肪组织特异性激活肾素血管紧张素系统以及脂肪细胞分化,导致 apoE-/- 小鼠动脉粥样硬化。
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[28.Irie D, Yamada H, Kato T, Kawahito H, Kishida S, Wakana N, Kensuke Fukui, Kouji Ikeda, Mitsuhiko Okigaki, Hiroaki Matsubara.]
通讯作者:
Hiroaki Matsubara.
DOI:
10.1161/atvbaha.114.305122
发表时间:
2015-03
期刊:
Arteriosclerosis, Thrombosis, and Vascular Biology
影响因子:
--
作者:
[Noriyuki Wakana;Daisuke Irie;M. Kikai;Kensuke Terada;Keita Yamamoto;Hiroyuki Kawahito;Taku Kato;T. Ogata;T. Ueyama;S. Matoba;H. Yamada]
通讯作者:
Noriyuki Wakana;Daisuke Irie;M. Kikai;Kensuke Terada;Keita Yamamoto;Hiroyuki Kawahito;Taku Kato;T. Ogata;T. Ueyama;S. Matoba;H. Yamada
Maternal high-fat diet exaggerates atherosclerosis development in adult offspring by augmenting periaortic adipose tissue-specific proinflammatory response.
母亲的高脂肪饮食通过增强主动脉周围脂肪组织特异性促炎症反应,加剧了成年后代动脉粥样硬化的发展。
DOI:
--
发表时间:
2014
期刊:
影响因子:
--
作者:
[Wakana N, Irie D, Kikai M, Terada K, Yamamoto Y, Kato T, Kawahito H, Yamada H.]
通讯作者:
Yamada H.
Transplantation of Periaortic Adipose Tissue from Angiotensin Receptor Blocker-treated Mice Markedly Ameliorates Atherosclerosis Development by Reducing Systemic Inflammatory State.
血管紧张素受体阻滞剂治疗小鼠的主动脉周围脂肪组织移植可通过减少全身炎症状态显着改善动脉粥样硬化的发展。
DOI:
--
发表时间:
期刊:
影响因子:
--
作者:
[59.入江大介, 若菜紀之, 鬼界雅一, 加藤拓, 岸田聡, 川人浩之, 山田浩之]
通讯作者:
山田浩之
Transplantation of high-cholesterol diet-induced inflammatory periaortic adipose tissue exaggerates atherosclerosis development in recipient apoE deficient mice.
高胆固醇饮食诱导的炎症性主动脉周围脂肪组织的移植会加剧 apoE 缺陷受体小鼠的动脉粥样硬化发展。
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[30.Irie D, Wakana N, Kikai M, Kato T, Kishida S, Kawahito H, Yamada H.]
通讯作者:
Yamada H.
共 7 条
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Understanding of the relationship between typhoon structure and intensity using Doppler radars in the Ryukyu Islands and Philippines
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The evaluation of the pathologic condition and the novel treatments in animal models of tinnitus
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Measurement of Nitrogen Compounds with IR-CRDS
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A Self-Adjusting Ossicular Prosthesis
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批准号:24659749
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Establishment of Safety Evaluation Guide Considering Real Usage Environment in Materials Used for High Pressure Hydrogen Gas Containers of Fuel-cell Vehicle
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Automatic classification of sidescan sonar image for mapping aquatic macrophyte distribution
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Establishment of salivary gland regeneration for salivary gland hypofunction : Approach to regeneration of blood vessels using dental pulp cells
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Fabrication and control of strongly-correlated-electron nano-magnetic interfaces toward applications to novel magneto-electric devices
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批准号:21750198
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Identification of a novel gene to promote atherosclerosis development by regulating fatty acid binding protein secreted from dysfunctional kidney
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Evaluation of the role of land surface conditions on the property of rainfall systems
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批准号:20740278
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资助金额:$2.91万
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The Sociological Study on the Learning Activities of Borderless University Students in Japan
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Protective effect of SOD on reactive oxygen species-induced salivary gland dysfunction.
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Investigation into the mechanism of tumorigenesis using p53-deficient epithelial cells
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Development of detailed chemical kinetic mechanism for bio-fuel
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批准号:18760159
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Development of an evaluation technique for heat island phenomenon and open space effect by using high resolution thermo graph data
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Analysis of the mechanisms for antiatherogenic effect of bone marrow AT2 receptor by using gene-targeted mice
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The Life History of Teachers in the Era of Marketization of Education
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Establishment of diagnostic system by immunohistochemistory using Tissue Microarray for human gastric cancer
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Land Price Fluctuations and their spread over metropolitan areas
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负责人:YAMADA Hiroyuki
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