Effects of molecular-targeted drugs on nonsmoking-related lung cancer models

分子靶向药物对非吸烟相关肺癌模型的影响

• 批准号: 24591182
• 负责人: TAKIGAWA Nagio
• 金额: $ 3.41万
• 依托单位: Kawasaki Medical School
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24591182/
• 关键词: EGFR; mTOR; JAK2; STAT3; 肺癌; 薬剤耐性; 遺伝子改変マウス; 血管新生

项目成果

Epidermal growth factor receptor signaling conferred acquired crizotinib resistance to a non-small cell lung cancer cell line harboring the SLC34A2-ROS1 fusion gene

表皮生长因子受体信号转导赋予携带 SLC34A2-ROS1 融合基因的非小细胞肺癌细胞系获得性克唑替尼耐药性

• 发表时间: 2014
• 作者: Kato Y;Ohashi K;Ichihara E;Isozaki H;Kudo K;Minami D;Kubo T;Sato A;Hotta K;Tabata M;Takigawa N;Tanimoto M;Kiura K
• 通讯作者: Kiura K

Everolimus prolonged survival in transgenic mice with EGFR-driven lung tumors.

• DOI: 10.1016/j.yexcr.2014.04.012
• 发表时间: 2014-08
• 期刊: Experimental cell research
• 影响因子: 3.7
• 作者: Masayuki Yasugi;N. Takigawa;N. Ochi;K. Ohashi;D. Harada;T. Ninomiya;T. Murakami;Y. Honda;E. Ichihara;M. Tanimoto;K. Kiura

ALK inactivation induced acquired resistance to alectinib in lung cancer harboring EML4-ALK fusion gene

ALK 失活诱导携带 EML4-ALK 融合基因的肺癌对艾乐替尼获得性耐药

• 发表时间: 2014
• 作者: Isozaki H;Ichihara E;Yasugi M;Ochi N;Hotta K;Takigawa N;Sendo T;Tanimoto M;Kiura K.
• 通讯作者: Kiura K.

PTEN deficient lung cancer cells are sensitive to the combination of olaparib with cisplatin through suppressing DNA damage signaling

PTEN 缺陷的肺癌细胞通过抑制 DNA 损伤信号传导对奥拉帕尼与顺铂的组合敏感

• 发表时间: 2013
• 作者: Minami Daisuke;Takigawa Nagio;Takeda Hiromasa;Takata Minoru;Ochi Nobuaki ;Ichihara Eiki;Hisamoto Akiko;Hotta Katsuyuki;Tanimoto Mitsune;Kiura Katsuyuki
• 通讯作者: Kiura Katsuyuki

The Role of STAT3 in Non-Small Cell Lung Cancer.

• DOI: 10.3390/cancers6020708
• 发表时间: 2014-03-26
• 期刊: Cancers
• 影响因子: 5.2
• 作者: Harada D;Takigawa N;Kiura K
• 通讯作者: Kiura K