Identification of human hematopoietic stem cell regulators with HLA allele deficient cells behavior
Identification of human hematopoietic stem cell regulators with HLA allele deficient cells behavior
批准号:
24790968
负责人:
KATAGIRI Takamasa
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
点击翻译按钮获取中文摘要
英文摘要
The percentage of 6pLOH was different among hematopoiesis stages in human bone marrow, and the progenitor cells showed much lower percentage of 6pLOH than that of MEP and GMP.I found approximately 30 times lower expression of CXCL12 which promotes the cell growth and proliferation cytokine than that of normal fraction with microarray analysis. As a result, I demonstrated the percentage of HLA deficient was significantly decreased, since the cell cycle was not promoted in the 6pLOH of CMP fraction with low CXCL12 and CXCR4 expression.
期刊论文(0)
专著(0)
科研奖励(0)
会议论文
登录
查看更多内容
Increased Gene Expression Of the Nr4A Family In Bone Marrow T Cells Of Patients With Early Stage Acquired Aplastic Anemia
早期获得性再生障碍性贫血患者骨髓 T 细胞中 Nr4A 家族基因表达增加
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[丸山 裕之, 佐治 博夫, 屋部登志雄, 柏瀬 貢一, 片桐 孝和, 材木 義隆, 斉藤 千鶴, 細川 晃平, 山崎 宏人, 小川 誠司, 中尾 眞二, Takamasa Katagiri, Kohei Hosokawa]
通讯作者:
Kohei Hosokawa
Prevalence of HLA-A allele lacking leukocytes in patients with aplastic anemia at diagnosis
再生障碍性贫血患者诊断时缺乏白细胞的 HLA-A 等位基因的患病率
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[丸山 裕之, 佐治 博夫, 屋部登志雄, 柏瀬 貢一, 片桐 孝和, 材木 義隆, 斉藤 千鶴, 細川 晃平, 山崎 宏人, 小川 誠司, 中尾 眞二, Takamasa Katagiri, Kohei Hosokawa, Hiroyuki Maruyama, Tetsuichi Yoshizato, Takamasa Katagiri, Yoshiki Akatsuka, Chizuru Saito, Tetsuichi Yoshizato, Hiroyuki Maruyama]
通讯作者:
Hiroyuki Maruyama
Immunologically escaped hematopoiesis caused by HLA allelic loss in patients with aplastic anemia
再生障碍性贫血患者 HLA 等位基因缺失导致免疫逃逸造血
DOI:
--
发表时间:
2012
期刊:
Rinsho Ketsueki
影响因子:
--
作者:
[Takamasa Katagiri, Shinji Nakao]
通讯作者:
Shinji Nakao
Evidence That GPI-AP-Specific CTLs Are Not Involved In The “escape” Of Piga mutant Hematopoietic Stem Cells In Aplastic Anemia
证据表明 GPI-AP 特异性 CTL 不参与再生障碍性贫血中 Piga 突变造血干细胞的“逃逸”
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Takamasa Katagiri, Hiroyuki Maruyama, Shigeki Ohtake, Chizuru Saito, Kohei Hosokawa, Seishi Ogawa, and Shinji Nakao]
通讯作者:
and Shinji Nakao
Escape hematopoiesis by HSC with somatic SLIT1 mutaions in patients with acquired aplastic anemia
获得性再生障碍性贫血患者体细胞 SLIT1 突变的 HSC 逃逸造血
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Chizuru Saito, Kohei Hosokawa, Hiroyuki Maruyama, Takamasa Katagiri, Akinori Kanai, Hirotaka Matsui, Toshiya Inaba, Akari Kazami, Masafumi Taniwaki, Hirohito Yamazaki, Shinji Nakao]
通讯作者:
Shinji Nakao
共 29 条
Elucidation of the pahogenesis of auto immune-bone marrow failure with human hematopoietic stem cells derived from iPS cells
-
批准号:17K09007
-
项目类别:Grant-in-Aid for Scientific Research (C)
-
资助金额:$3.08万
-
财政年份:2017
-
负责人:KATAGIRI Takamasa
-
依托单位:
Analysis of human haematopietic stem cell movement with PNH-type cell.
-
批准号:26860363
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.58万
-
财政年份:2014
-
负责人:KATAGIRI Takamasa
-
依托单位:
海外基金