Analysis of progression of atherosclerosis after Kawasaki disease by coronary arteritis mouse model

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Nod1 ligand induces Kawasaki disease-like coronary arteritis in mice. After coronary arteritis developed in ApoE KO mice by administration of Nod1 ligand, the progression of atherosclerosis was assessed. Atherosclerosis in coronary artritis-induced ApoE KO mice was progressed more than in not induced ApoE KO mice. And the progression was caused by production of cytokines and chemokines like Ccl5 and Cxcl16 in coronary artery. Furthermore, atherosclerosis in Nod1/ApoE double knockout mice progressed more slowly than that in ApoE KO mice. These finginds suggested that innate immune ligands possibly caused by Kawasaki disease would progress atherosclerosis.