Examination of the neurodevelopmentally hypothesis using the prenatal glucocorticoid exposure model

在本研究中，我们分析了产前糖皮质激素对皮质形成、神经元分化和神经元网络的影响。当原代培养的海马神经元细胞被给予皮质酮时，西班牙的caldesmon通过血清反应因子以浓度依赖的方式降低它，并破坏F-肌动蛋白的稳定。在用扩散张量成像分析了糖皮质激素暴露的青春期大鼠后脑白质中神经网络的形成后，我们发现糖皮质激素暴露组的轴突血流变得更加各向异性。如上所述，我们证实了胎儿期接触糖皮质激素对大脑发育的影响。

In this study, we analyzed the effect of prenatal glucocorticoid on the cortical formation, neuronal differentiation and neuronal network. When the primary hippocampal neuron cultured cell was given a corticosterone, caldesmon in the spain decreased it in concentration-dependency through a serum response factor and destabilized the F-actin. As a result of having analyzed neural network formation in the posterior white matter of the glucocorticoid exposed adolescent rat by diffusion tensor imaging, we revealed that an axonal flow became more anisotropic in the glucocorticoid exposure group. As above, we confirmed that the brain development was affected by the prenatal glucocorticoid exposure.