Examination of the neurodevelopmentally hypothesis using the prenatal glucocorticoid exposure model

本研究分析了产前糖皮质激素对脑皮质发育、神经元分化和神经元网络的影响。当原代海马神经元培养细胞给予皮质酮时，西班牙的caldesmon通过血清反应因子以浓度依赖性降低皮质酮，并使F-肌动蛋白不稳定。通过扩散张量成像分析了糖皮质激素暴露的青春期大鼠的后部白色物质中的神经网络形成，我们发现，在糖皮质激素暴露组中，轴突流变得更加各向异性。综上所述，我们证实了产前糖皮质激素暴露对脑发育的影响。

In this study, we analyzed the effect of prenatal glucocorticoid on the cortical formation, neuronal differentiation and neuronal network. When the primary hippocampal neuron cultured cell was given a corticosterone, caldesmon in the spain decreased it in concentration-dependency through a serum response factor and destabilized the F-actin. As a result of having analyzed neural network formation in the posterior white matter of the glucocorticoid exposed adolescent rat by diffusion tensor imaging, we revealed that an axonal flow became more anisotropic in the glucocorticoid exposure group. As above, we confirmed that the brain development was affected by the prenatal glucocorticoid exposure.