Effect of prenatal glucocorticoid exposure on the cortical development and network

产前糖皮质激素暴露对皮质发育和网络的影响

• 批准号: 22791124
• 负责人: FUKUMOTO Kentaro
• 金额: $ 2.5万
• 依托单位: Iwate Medical University (2011)Osaka University (2010)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22791124/
• 关键词: グルココルチコイド; 介在ニューロン; 接線方向移動; 拡散テンソル画像; 神経ネットワーク

The neurodevelopmental hypothesis is proposed as one of the hypotheses to explain critical cause of the mental disorder. This is the theory that fetal brain development abnormality may make an onset risk of mental disorder. In this study, we examined the effect of prenatal glucocorticoid hormone exposure on the cerebral cortex formation/neural network formation of rodent. This study has revealed so far that the glucocorticoid exposure disturbs the migration of interneuron which is to become GABAergic neuron and causes the heterogeneous distribution in the cortex. Furthermore, it has also revealed that prenatal glucocorticoid exposure reduces the volume of the prefrontal cortex and causes the anisotropy anomaly in the white matter in peri-adolescent period.

神经发育假说被提出作为解释精神障碍关键原因的假说之一。这一理论认为胎儿大脑发育异常可能会导致精神障碍的发病风险。本研究探讨了产前糖皮质激素暴露对鼠类大脑皮层形成/神经网络形成的影响。本研究迄今发现，糖皮质激素暴露干扰了向gaba能神经元过渡的中间神经元的迁移，导致其在皮层内的不均匀分布。此外，研究还揭示了产前糖皮质激素暴露减少了前额皮质的体积，并导致了青春期前后白质的各向异性异常。

项目成果

Caldesmon, an actin-linked regulatory protein, comes across glucocorticoids

Caldesmon 是一种肌动蛋白连接的调节蛋白，与糖皮质激素相结合

• 发表时间: 2010
• 期刊: Cell Adhesion & Migration
• 影响因子: 3.2
• 作者: K. Sobue;Kentaro Fukumoto
• 通讯作者: Kentaro Fukumoto