The study of radiosensitive effect through delatation of tumor vessels with nitroglycerin

点击翻译按钮获取中文摘要

We examined whether nitroglycerin (NTG), which is a effective vasodilator, have an influence on radiosensitivity of cancers through reoxygenation of tumor tissue. The concentration allowable to a livingbody of NTG presented no radiosensitivity in A549 cells, although NTG increased the expression of HIF1alpha and ATM proteins. This study suggested that intracellular reactive oxygen species, including nitric oxide induced by NTG, are involved with megakaryocytopoiesis of K562 chronic leukemia cells.The administration of NTG just before irradiation of 10 Gy presented no radisensitivity on SAS tumor xenograft mouse model. However, NTG increased partial oxygen pressure of the tumor tissue slowly and transiently without the change of the tumor blood flow.