The study of radiosensitive effect through delatation of tumor vessels with nitroglycerin

硝酸甘油扩张肿瘤血管放射增敏作用的研究

• 批准号: 24791266
• 负责人: HIROSE Katsumi
• 金额: $ 2.75万
• 依托单位: Hirosaki University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791266/
• 关键词: ニトログリセリン; 放射線増感; A549; 低酸素細胞; HIF-1a

We examined whether nitroglycerin (NTG), which is a effective vasodilator, have an influence on radiosensitivity of cancers through reoxygenation of tumor tissue. The concentration allowable to a livingbody of NTG presented no radiosensitivity in A549 cells, although NTG increased the expression of HIF1alpha and ATM proteins. This study suggested that intracellular reactive oxygen species, including nitric oxide induced by NTG, are involved with megakaryocytopoiesis of K562 chronic leukemia cells.The administration of NTG just before irradiation of 10 Gy presented no radisensitivity on SAS tumor xenograft mouse model. However, NTG increased partial oxygen pressure of the tumor tissue slowly and transiently without the change of the tumor blood flow.

我们研究了硝酸甘油（NTG），这是一种有效的血管扩张剂，是否通过肿瘤组织的复氧对癌症的放射敏感性产生影响。 在活体允许浓度下，NTG对A549细胞无辐射敏感性，但NTG可增加HIF 1 α和ATM蛋白的表达。提示NTG诱导的细胞内活性氧包括NO参与了K562细胞的巨核生成，在10戈伊照射前给予NTG对SAS肿瘤异种移植小鼠模型无放射敏感性。NTG可缓慢而短暂地增加肿瘤组织的氧分压，但肿瘤血流量无明显变化。

项目成果

Effects of radiation on the maturation of megakaryocytes.

• DOI: 10.1093/jrr/rrs127
• 发表时间: 2013-05
• 期刊: Journal of radiation research
• 影响因子: 2
• 作者: Hirose K;Monzen S;Yoshino H;Sato H;Aoki M;Hatayama Y;Kawaguchi H;Sato M;Narita Y;Takai Y;Kashiwakura I
• 通讯作者: Kashiwakura I