Regulation of development and inflammation through regulating IL-1 expression by Blimp1

骨体积在骨吸收破骨细胞和骨形成成骨细胞之间的微妙平衡中受到严格控制。该申请人证明，Blimp1是促进破骨细胞分化所必需的，破骨细胞特异性Blimp1条件敲除小鼠表现出明显的破骨细胞生成抑制，同时骨量显著升高。该申请人还发现，在血细胞以外的细胞中，Blimp1的条件失活会导致骨量和炎症表型的显著减少。

Bone volume is tightly controlled in a delicate balance between bone resorbing osteoclasts and bone forming osteoblasts. This applicant demonstrated that Blimp1 was required to promote osteoclast differentiation, and osteoclast specific Blimp1 conditional knockout mice exhibited significant inhibition of osteoclastogenesis accompanied with significant elevation of bone mass. This applicant also found that conditional inactivation of Blimp1 in cells other than blood cells resulted in significant reduction of bone mass and inflammatory phenotypes.