Regulation of development and inflammation through regulating IL-1 expression by Blimp1

Blimp1 通过调节 IL-1 表达来调节发育和炎症

• 批准号: 24791561
• 负责人: SATO Yuiko
• 金额: $ 2.75万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791561/
• 关键词: 骨; Blimp1; 炎症; 成長

Bone volume is tightly controlled in a delicate balance between bone resorbing osteoclasts and bone forming osteoblasts. This applicant demonstrated that Blimp1 was required to promote osteoclast differentiation, and osteoclast specific Blimp1 conditional knockout mice exhibited significant inhibition of osteoclastogenesis accompanied with significant elevation of bone mass. This applicant also found that conditional inactivation of Blimp1 in cells other than blood cells resulted in significant reduction of bone mass and inflammatory phenotypes.

骨体积在骨再吸收破骨细胞和骨形成成骨细胞之间的微妙平衡中被严格控制。本申请人证明了Blimp 1是促进破骨细胞分化所必需的，破骨细胞特异性Blimp 1条件性敲除小鼠表现出对破骨细胞生成的显著抑制，伴随着骨量的显著升高。该申请人还发现，Blimp 1在除血细胞以外的细胞中的条件性失活导致骨量和炎性表型的显著减少。

项目成果

Aldehyde-stress resulting from Aldh2 mutation promotes osteoporosis due to impaired osteoblastogenesis

• DOI: 10.1002/jbmr.1634
• 发表时间: 2012-09-01
• 期刊: JOURNAL OF BONE AND MINERAL RESEARCH
• 影响因子: 6.2
• 作者: Hoshi, Hiroko;Hao, Wu;Miyamoto, Takeshi
• 通讯作者: Miyamoto, Takeshi

An Essential Role for STAT6-STAT1 Protein Signaling in Promoting Macrophage Cell-Cell Fusion

• DOI: 10.1074/jbc.m112.358226
• 发表时间: 2012-09-21
• 期刊: JOURNAL OF BIOLOGICAL CHEMISTRY
• 影响因子: 4.8
• 作者: Miyamoto, Hiroya;Katsuyama, Eri;Miyamoto, Takeshi
• 通讯作者: Miyamoto, Takeshi