Establishment of a novel sarcopenia mouse model by reducing serum IGF1 and development of a way for sarcopenia treatment by using the model

降低血清IGF1建立新型肌少症小鼠模型及利用该模型开发肌少症治疗途径

• 批准号: 19K09580
• 负责人: SATO Yuiko
• 金额: $ 2.75万
• 依托单位: Keio University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2019
• 资助国家: 日本
• 起止时间: 2019-04-01 至 2022-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-19K09580/
• 关键词: サルコペニア; 整形外科

项目成果

Transient alendronate administration to pregnant or lactating mothers prevents bone loss in mice without adverse effects on offspring

孕妇或哺乳期母亲短暂服用阿仑膦酸钠可防止小鼠骨质流失，且不会对后代产生不良影响

• DOI: 10.1016/j.bone.2021.116133
• 发表时间: 2021
• 期刊: Bone
• 影响因子: 4.1
• 作者: Ito Eri;Sato Yuiko;Kobayashi Tami;Soma Tomoya;Matsumoto Tatsuaki;Kimura Atsushi;Miyamoto Kana;Matsumoto Hideo;Matsumoto Morio;Nakamura Masaya;Sato Kazuki;Miyamoto Takeshi
• 通讯作者: Miyamoto Takeshi

Treatment with an active vitamin D analogue blocks hypothalamic dysfunction-induced bone loss in mice

活性维生素 D 类似物治疗可阻止小鼠下丘脑功能障碍引起的骨质流失

• DOI: 10.1016/j.bbrc.2021.01.026
• 发表时间: 2021
• 期刊: Biochem Biophys Res Commun
• 作者: Ito E;Sato Y;Kobayashi T;Nakamura S;Kaneko Y;Soma T;Matsumoto T;Kimura A;Miyamoto K;Matsumoto H;Matsumoto M;Nakamura M;Sato K;Miyamoto T
• 通讯作者: Miyamoto T

Synoviolin is not a pathogenic factor for auto-inflammatory diseases

滑膜蛋白不是自身炎症性疾病的致病因素

• DOI: 10.1016/j.bbrc.2021.04.093
• 发表时间: 2021
• 期刊: Biochemical and Biophysical Research Communications
• 影响因子: 3.1
• 作者: Matsumoto Tatsuaki;Sato Yuiko;Kobayashi Tami;Ito Eri;Soma Tomoya;Kimura Atsushi;Miyamoto Kana;Kobayashi Shu;Harato Kengo;Matsumoto Morio;Nakamura Masaya;Niki Yasuo;Miyamoto Takeshi
• 通讯作者: Miyamoto Takeshi

Smad2 and Smad3 expressed in skeletal muscle promote immobilization-induced bone atrophy in mice

骨骼肌中表达的 Smad2 和 Smad3 促进小鼠固定诱导的骨萎缩

• DOI: 10.1016/j.bbrc.2021.10.043
• 发表时间: 2021
• 期刊: Biochemical and Biophysical Research Communications
• 影响因子: 3.1
• 作者: Umezu Taro;Nakamura Satoshi;Sato Yuiko;Kobayashi Tami;Ito Eri;Abe Takaya;Kaneko Mari;Nomura Masatoshi;Yoshimura Akihiko;Oya Akihito;Matsumoto Morio;Nakamura Masaya;Kanaji Arihiko;Miyamoto Takeshi
• 通讯作者: Miyamoto Takeshi

Adipose-Derived Stem Cell Sheets Improve Early Biomechanical Graft Strength in Rabbits After Anterior Cruciate Ligament Reconstruction

• DOI: 10.1177/03635465211041582
• 发表时间: 2021-10
• 期刊: The American Journal of Sports Medicine
• 作者: Tatsuaki Matsumoto;Yuiko Sato;Tami Kobayashi;Kunika Suzuki;Atsushi Kimura;T. Soma;Eri Ito;Toshiyuki Kikuchi;S. Kobayashi;K. Harato;Y. Niki;M. Matsumoto;M. Nakamura;T. Miyamoto