Development of intraoperative navigation system for robot-assisted radical prostatectomy utilizing two-photon microscope

双光子显微镜机器人辅助前列腺癌根治术术中导航系统的研制

• 批准号: 24791647
• 负责人: HINATA Nobuyuki
• 金额: $ 2.5万
• 依托单位: Kobe University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791647/
• 关键词: 骨盤内神経; ロボット支援手術; 自律神経; 根治的前立腺全摘除術; 術中ナビゲーション; 前立腺癌; 機能温存; 骨盤内神経解剖学; 二光子励起蛍光顕微鏡

The aim of the present study was to analyze a feasibility of utilizing two-photon microscope in the intraoperative navigation system for robot-assisted radical prostatectomy. Male rats were observed and sacrificed, then the tissues were stained using H-E staining, Masson-Trichrome staining, anti-thyroxin Hydroxidase immunostaining, and anti-nNOS immunostaining. Although it was difficult to set suitable wavelength to observe the autonomic nerves in the rat pelvis, we obtained ideas from the present study and reported some observations about neuroanatomy for pelvic organs and intraoperative imaging systems derived from the present study.

本研究的目的是分析在机器人辅助前列腺癌根治术中导航系统中使用双光子显微镜的可行性。观察并处死雄性大鼠，进行H-E染色、Masson-trichrome染色、抗甲状腺激素羟化酶免疫染色、抗nNOS免疫染色。虽然很难设置合适的波长来观察大鼠盆腔的自主神经，但我们从本研究中获得了一些想法，并报道了本研究中对盆腔器官和术中影像系统的一些神经解剖学观察。

项目成果

Dry box training with three-dimensional vision for the assistant surgeon in robot-assisted urological surgery.

机器人辅助泌尿外科手术助理外科医生的三维视觉干箱培训。

• DOI: 10.1111/iju.12101
• 发表时间: 2013
• 期刊: Int J Urol.
• 作者: Hinata N;Iwamoto H;Morizane S;Hikita K;Yao A;Muraoka K;Honda M;Isoyama T;Sejima T;Takenaka A.
• 通讯作者: Takenaka A.

Coexistence of Elastic Fibers with Hyaluronic Acid in the Human Urethral Sphincter Complex: A Histological Study

• DOI: 10.1016/j.juro.2013.04.023
• 发表时间: 2013-10-01
• 期刊: JOURNAL OF UROLOGY
• 影响因子: 6.6
• 作者: Hinata, Nobuyuki;Murakami, Gen;Takenaka, Atsushi
• 通讯作者: Takenaka, Atsushi