investigation of novel classificaitons of diabetic macular edema using self-organizing map

我用光学相干断层扫描（OCT）研究了糖尿病性黄斑水肿（DME）的发病机制。我建立了一个新的方法分割的内部和外部的视网膜层，以下这些层的测量。其次，对视网膜中央凹感光细胞的异常机制进行了比较研究，发现高反射灶、外界膜、内外节连接处与视网膜中央凹感光细胞异常之间存在联系。此外，我证明了浆液性视网膜脱离和中心凹囊样间隙的发病机制，这取决于中心凹周围的视网膜血管通透性过高或中心凹或旁凹的视网膜血管改变。最后，我们应用自组织映射进行多维数据的分析，并显示了OCT结果或参数的新关联和分离，并提出了一种新的糖尿病性黄斑水肿的形态学模式分类

I investigated the pathogenesis of diabetic macular edema (DME) using optical coherence tomography (OCT). I established a novel methods for the segmentation of inner and outer retinal layers, following the measurements of these layers. Second, I performed the comparative study about the mechanisms of distrubance in foveal photoreceptor, and found the association between hyperreflective foci, external limiting membrane, the junction of inner and outer segments of photoreceptor cells. In addition, I demonstrated the pathogenesis of the development of serous retinal detachment and foveal cystoid spaces, depending on either retinal vascular hyperpermeability in the perifovea or the retinal vascular changes in the fovea or parafovea.Finally, we applied self-organizing map for the analyses of multi-dimensional data, and showed novel associations and dissociations of OCT findings or parameters, and proposed a novel classification of morphological patterns in dmabetic macular edema