investigation of novel classificaitons of diabetic macular edema using self-organizing map

使用自组织图研究糖尿病性黄斑水肿的新分类

• 批准号: 24791849
• 负责人: MURAKAMI Tomoaki
• 金额: $ 2.66万
• 依托单位: Kyoto University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24791849/
• 关键词: 糖尿病黄斑浮腫; 漿液性網膜剥離; 嚢胞様腔; 血管透過性亢進; 黄斑部視細胞障害; 自己組織化マップ; 画像解析; パターン認識; 臨床診断

I investigated the pathogenesis of diabetic macular edema (DME) using optical coherence tomography (OCT). I established a novel methods for the segmentation of inner and outer retinal layers, following the measurements of these layers. Second, I performed the comparative study about the mechanisms of distrubance in foveal photoreceptor, and found the association between hyperreflective foci, external limiting membrane, the junction of inner and outer segments of photoreceptor cells. In addition, I demonstrated the pathogenesis of the development of serous retinal detachment and foveal cystoid spaces, depending on either retinal vascular hyperpermeability in the perifovea or the retinal vascular changes in the fovea or parafovea.Finally, we applied self-organizing map for the analyses of multi-dimensional data, and showed novel associations and dissociations of OCT findings or parameters, and proposed a novel classification of morphological patterns in dmabetic macular edema

我用光学相干断层扫描(OCT)研究了糖尿病黄斑水肿(DME)的发病机制。我建立了一种新的方法来分割视网膜内层和外层，遵循这些层的测量。其次，对黄斑中心凹感光细胞运动障碍的机制进行了比较研究，发现了高反射灶、外界膜、感光细胞内外节段的连接之间的联系。此外，我们还论证了浆液性视网膜脱离和黄斑中心凹囊样间隙的形成机制，这取决于视网膜血管在黄斑周围的高通透性或黄斑中心凹或黄斑旁的视网膜血管改变。最后，我们应用自组织映射图对多维数据进行分析，显示了OCT表现或参数的新的关联和分离，并提出了一种新的黄斑水肿的形态模式分类。

项目成果

Segmentational Analysis of Retinal Thickness after Vitrectomy in Diabetic Macular Edema

• DOI: 10.1167/iovs.12-9934
• 发表时间: 2012-09-01
• 期刊: INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE
• 影响因子: 4.4
• 作者: Murakami, Tomoaki;Nishijima, Kazuaki;Yoshimura, Nagahisa
• 通讯作者: Yoshimura, Nagahisa

Association between cystoid spaces on indocyanine green hyperfluorescence and optical coherence tomography after vitrectomy for diabetic macular oedema.

糖尿病黄斑水肿玻璃体切除术后吲哚菁绿超荧光囊样空间与光学相干断层扫描之间的关联。

• DOI: 10.1038/eye.2013.290
• 发表时间: 2014
• 期刊: Eye
• 影响因子: 3.9
• 作者: Yoshitake S;Murakami T;Uji A;Ogino K;Horii T;Hata M;Arichika S;Nishijima K;Yoshimura N.
• 通讯作者: Yoshimura N.

Author response : macular migration toward the optic disc after inner limiting membrane peeling for diabetic macular edema

作者回应：糖尿病黄斑水肿内界膜剥离后黄斑向视神经盘迁移

• 发表时间: 2013
• 期刊: Invest Ophthalmol Vis Sci
• 作者: Yoshikawa M;Murakami T
• 通讯作者: Murakami T

Annexin V inhibits pathological retinal angiogenesis but not physiological retinal vascular development

膜联蛋白 V 抑制病理性视网膜血管生成，但不抑制生理性视网膜血管发育

• 发表时间: 2013
• 作者: Morooka S;Murakami T;Nukada M;Yoshimura N
• 通讯作者: Yoshimura N

Clinical Relevance of Optical Coherence Tomographic Reflectivity in Cystoid Spaces in Eyes treated with Triamcinolone for Diabetic Macular Edema

曲安奈德治疗糖尿病性黄斑水肿眼囊囊腔光学相干断层扫描反射率的临床相关性

• 发表时间: 2012
• 作者: Horii T;Murakami T;Nishijima K;Akagi T;Uji A;Ueda-Arakawa N;Yoshimura N
• 通讯作者: Yoshimura N