Mechanism and control of inflammation and organ failure in crush syndrome.

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Patients with crush injury often present systemic inflammatory response syndrome and fall into multiple organ failure, but the mechanism is still unclear. We focused on RAGE.(1)In Rat model of crush injury, administration of anti-RAGE antibody reduced inflammatory reaction and improved survival. (2)Patient with SIRS, serum soluble RAGE increased significantly than normal. Soluble RAGE was related to serum HMGB1 or acute DIC score. Expression of RAGE reflect to serum soluble RAGE. In patients with SIRS, RAGE expression may be increased.These results indicate blocking of RAGE such as anti-RAGE antibody may become a promising novel therapy against crush syndrome or SIRS.