Elucidation of the mechanism of dentin regeneration focused on reprogramming of human dental pulp cells mediated by TNF-alpha
Elucidation of the mechanism of dentin regeneration focused on reprogramming of human dental pulp cells mediated by TNF-alpha
批准号:
24792084
负责人:
UEDA Mayu
金额:
$2.75万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Young Scientists (B)
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-04-01 至 2014-03-31
中文摘要
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英文摘要
The purpose of this study is to investigate the effects of a treatment with TNF-alpha on the stem cell phenotype and differentiation ability of human dental pulp cells, and elucidate of the mechanism of dentin regeneration.In conclusion, our data show that a short-term treatment with TNF-alpha significantly increases the stem cell phenotype of DPCs as well as their function and multipotent differentiation ability. Additionally, our findings also demonstrate that the reprogramming depend on TNF-alpha specifically and NF-kB is not the only pathway involved in the TNF-alpha-enhanced stem cell phenotype of DPCs.
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A comparative analysis of the effect of rhTNF-αtreatment on the stem cell phenotype of cells derived from dental pulp,periodontal ligament and bone marrow
rhTNF-α处理对牙髓、牙周膜和骨髓来源细胞干细胞表型影响的比较分析
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Pham TH, Ono M, Hara ES, Ueda M, Sonoyama W, Lieu PV, Kuboki T]
通讯作者:
Kuboki T
A short-term treatment with TNF-α enhances the stem cell phenotype of human dental pulp cells.
TNF-α 的短期治疗可增强人牙髓细胞的干细胞表型。
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[Ueda M, Pham HT, Fujisawa T, Ono M, Hara ES, Sonoyama W, Pham LV, Kuboki T]
通讯作者:
Kuboki T
Effect of transient TNF-αtreatment on the stem cell phenotype of human periodontal ligament cells and bone marrow stromal cells
瞬时TNF-α处理对人牙周膜细胞和骨髓基质细胞干细胞表型的影响
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Pham TH, Ono M, Hara ES, Ueda M, Sonoyama W, Lieu PV, Kuboki T]
通讯作者:
Kuboki T
炎症環境による歯髄細胞の幹細胞化―歯髄細胞分化に与えるTNF-αの影響―
炎症环境对牙髓细胞的干化作用 - TNF-α对牙髓细胞分化的影响 -
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[上枝麻友, 藤澤拓生, 大野充昭, 正木明日香, 三木春奈, 園山亘, 窪木拓男]
通讯作者:
窪木拓男
歯髄細胞のリプログラミングに対するTNF-αの効果
TNF-α对牙髓细胞重编程的影响
DOI:
--
发表时间:
2011
期刊:
影响因子:
--
作者:
[上枝麻友, 藤澤拓生, 大野充昭, 正木明日香, 三木春奈, 園山亘, 窪木拓男]
通讯作者:
窪木拓男
共 6 条
Development of new dental pulp capping material applied effect of reprograming of dental pulp cells by TNF-alpha
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批准号:26861640
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项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.41万
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财政年份:2014
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负责人:UEDA Mayu
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依托单位:
海外基金