A search and evaluation of the peptides that control the connective tissue growth factor for the prevention and the treatment of osteoarthritis.

寻找和评估控制结缔组织生长因子的肽，以预防和治疗骨关节炎。

• 批准号: 24792142
• 负责人: OIDA Yasutaka
• 金额: $ 2.75万
• 依托单位: Okayama University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24792142/
• 关键词: ハルミン; CCN2; β-カルボリン; 軟骨細胞; 軟骨再生; Harmine; 変形性関節症; 軟骨分化; 結合組織成長因子 CTGF

CCN2 / connective tissue growth factor (CTGF) has been reported to have essential role in cartilage development, chondrocyte proliferation and differentiation as well as regulation of the extracellular matrix metabolism. This study screened a compound library and identified harmine as a novel inducer of CCN2. This finding indicates harmine as a potential drug for prevention and / or repair of cartilage degradation.

CCN 2/结缔组织生长因子（CTGF）在软骨发育、软骨细胞增殖和分化以及调节细胞外基质代谢中具有重要作用。本研究筛选了一个化合物库，并鉴定了去氢骆驼蓬碱作为一种新的CCN 2诱导剂。这一发现表明去氢骆驼蓬碱作为预防和/或修复软骨退化的潜在药物。

项目成果

Harmine, an inducer of CCN2/CTGF, promotes chondrogenesis and rescues TNF-α-induced downregulation of cartilage markers

Harmine 是 CCN2/CTGF 的诱导剂，可促进软骨形成并挽救 TNF-α 诱导的软骨标志物下调

• 发表时间: 2011
• 作者: Hara ES;Ono M;Kubota S;Sonoyama W;Hattori T;Nishida T;Takigawa M;Kuboki T
• 通讯作者: Kuboki T

The CCN2-inducer Harmine promotes chondrogenesis and protection against TNFα-induced inflammation.

CCN2 诱导剂 Harmine 促进软骨形成并预防 TNFα 诱导的炎症。

• 发表时间: 2012
• 作者: Hara;E.;Ono;M.;Kubota;S.;Sonoyama;W.;Oida;Y.;Hattori;T.;Nishida;T.;Furumatsu;T.;Ozaki;T.;Takigawa;M.;Kuboki;T
• 通讯作者: T

Harmine, an inducer of CCN2/CTGF, promotes chondrogenesis and suppresses TNF-α-induced inflammatory response

Harmine 是 CCN2/CTGF 的诱导剂，可促进软骨形成并抑制 TNF-α 诱导的炎症反应

• 发表时间: 2011
• 作者: Emilio Satoshi Hara;Mitsuaki Ono;Satoshi Kubota;Wataru Sonoyama;Takako Hattori;他
• 通讯作者: 他

Harmine, an inducer of CCN2/CTGF, promotes chondrogenesis and protection against TNF-α-induced inflammatory condition

Harmine 是 CCN2/CTGF 的诱导剂，可促进软骨形成并预防 TNF-α 诱导的炎症状况

• 发表时间: 2011
• 作者: Emilio Satoshi Hara;et al
• 通讯作者: et al

Enhanced TGFβ3-induced chondrogenesis of ATDC5 cells by fluocinolone acetonide.

氟轻松增强 TGFβ3 诱导的 ATDC5 细胞软骨形成。

• 发表时间: 2012
• 作者: Hara ES;Ono M;Kubota S;Sonoyama W;Fujisawa T;Takigawa M;Kuboki T.
• 通讯作者: Kuboki T.