Antitumor effects of telomerase-specific replication-selective oncolytic viruses for adenoid cystic carcinoma cell lines.

点击翻译按钮获取中文摘要

We describe the mechanistic basis for synergy of virotherapy. Our data clearly indicate that telomerase-specific replication-selective oncolytic adenoviruses can significantly inhibit ACC cell growth in vitro and in vivo. Moreover, these viruses can be used in an ex vivo diagnostic assay to predict the therapeutic potential of virus in ACC patients.27 This novel technology will affect and contribute to the minimum operative procedure for ACC cancer patients.