Mechanism of neurite outgrowth promoting effect of LOTUS, an antagonist for Nogo receptor
Mechanism of neurite outgrowth promoting effect of LOTUS, an antagonist for Nogo receptor
批准号:
24890187
负责人:
KURIHARA Yuji
金额:
$1.66万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Research Activity Start-up
财政年份:
2012
资助国家:
日本
项目状态:
已结题
起止时间:
2012-08-31 至 2014-03-31
中文摘要
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英文摘要
LOTUS functions as the antagonist for Nogo receptor-1 (NgR1) which restricts functional recovery after damages to the central nervous system. We found that LOTUS also promotes neurite outgrowth. In this study, I analyzed the promoting effect of LOTUS on neurite outgrowth. Using the neurons from ngr1-deficient mice, I investigated the molecule(s) which mediate the promoting effect of LOTUS on neurite outgrowth. I found that LOTUS interacts with the molecule(s) except for NgR1 and the unidentified LOTUS binding molecule(s) mediate the promoting action of LOTUS on neurite outgrowth.
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LOTUSの神経突起伸長作用
LOTUS 的神经突生长作用
DOI:
--
发表时间:
2013
期刊:
影响因子:
--
作者:
[栗原裕司, 伊藤拓夢, 池谷真澄, 五嶋良郎, 竹居光太郎]
通讯作者:
竹居光太郎
LOTUS functions as a potent antagonist for Nogo receptor
LOTUS 作为 Nogo 受体的有效拮抗剂
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[Kurihara Y, Iketani M, Ito H, Nishiyama K, Sakakibara Y, Goshima Y, Takei K]
通讯作者:
Takei K
LOTUSによる神経回路形成機構
LOTUS的神经回路形成机制
DOI:
--
发表时间:
2013
期刊:
Annual Review 2013 神経
影响因子:
--
作者:
[栗原裕司, 竹居光太郎]
通讯作者:
竹居光太郎
Nogo受容体に対するLOTUSの拮抗作用
LOTUS 对 Nogo 受体的拮抗作用
DOI:
--
发表时间:
2012
期刊:
影响因子:
--
作者:
[栗原裕司、池谷真澄、伊藤拓夢、西山邦幸, 榊原裕介、五嶋良郎、竹居光太郎]
通讯作者:
榊原裕介、五嶋良郎、竹居光太郎
Regulation of neurite outgrowth mediated by localized phosphorylation of protein translational factor eEF2 in growth cones
生长锥中蛋白质翻译因子 eEF2 局部磷酸化介导的神经突生长调节
DOI:
10.1002/dneu.22058
发表时间:
2013
期刊:
Dev. Neurosci
影响因子:
--
作者:
[Iketani M., Iizuka A., Sengoku K., Kurihara Y., Nakamura F., Sasaki Y., Sato Y., Yamane M., Matsushita M., Nairn A.C., Takamatsu K., Goshima Y., Takei K.]
通讯作者:
Takei K.
Regulation of PirB, a receptor causing neurodegenerative diseases
-
批准号:16K21268
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.66万
-
财政年份:2016
-
负责人:KURIHARA Yuji
-
依托单位:
Regulation of PirB, a functional receptor for axonal growth inhibitors, by LOTUS
-
批准号:26870480
-
项目类别:Grant-in-Aid for Young Scientists (B)
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资助金额:$2.5万
-
财政年份:2014
-
负责人:KURIHARA Yuji
-
依托单位:
Antitumor effects of telomerase-specific replication-selective oncolytic viruses for adenoid cystic carcinoma cell lines.
-
批准号:24792254
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.66万
-
财政年份:2012
-
负责人:KURIHARA Yuji
-
依托单位:
Telomerase-Specific Replication-Selective Virotherapy combined with radiation therapy for oral squamous cell carcinoma cells.
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批准号:22792013
-
项目类别:Grant-in-Aid for Young Scientists (B)
-
资助金额:$2.5万
-
财政年份:2010
-
负责人:KURIHARA Yuji
-
依托单位:
海外基金