b-Cryptoxanthin regulates bone resorption related cytokine production in human periodontal ligaments cells.

b-隐黄质（b-cry）是柑橘中含有丰富的类胡萝卜素。b-cry不仅具有抑制致癌作用和抗氧化作用，还可预防骨质疏松症和糖尿病，并可减少体内脂肪。这项研究表明，b-cry可以防止牙周炎骨吸收。此外，在牙龈卟啉单胞菌LPS刺激牙龈成纤维细胞之前添加b-cry后，炎症细胞因子的表达会减少。炎症细胞因子的产生通过抑制参与细胞内信号传导的ERK和p38的活性而被抑制。已经表明，b-cry是一种类胡萝卜素，可以预期对牙周炎的治疗和预防作用。

b-cryptoxanthin(b-cry) is a carotenoid that is contained in abundance in mandarin. b-cry not only inhibits carcinogenesis and has an antioxidative effect, it can also prevent osteoporosis and diabetes and can decrease body fat. This study suggest that b-cry may prevent bone resorption in periodontitis. In addition, inflammatory cytokine expression is decreased upon addition of b-cry before stimulation by P. gingivalis LPS in gingival fibroblasts. Production of inflammatory cytokines was suppressed by the inhibition of the activity of the ERK and p38 that are involved in intracellular signaling .It has been suggested that, b-cry is a carotenoid that can be expected therapeutic and preventive effect on periodontitis.