Endocine cell tumors of gastrointestinal tract : characteristics and histogenesis

胃肠道内分泌细胞肿瘤：特征和组织发生

• 批准号: 04807022
• 负责人: IWAFUCHI Mitsuya
• 金额: $ 1.15万
• 依托单位: Niigata University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for General Scientific Research (C)
• 财政年份: 1992
• 资助国家: 日本
• 起止时间: 1992 至 1993
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-04807022/
• 关键词: Carcinoid; Endocrine cell carcinoma; APUDoma; Paraneuroma; Gut hormone; Cell culture; 消化管; 内分泌細胞腫瘍; 分子病理; カルテノイド腫瘍; 内分泌細胞; PCNA; P53; K-ras

During the period of past two years of this particular project, endocrine cell tumors of the gastrointestinal tract of Japanese were collected and analyzed.1. Endocrine cell tumors of the gastrointestinal tract were divided into two groups : carcinoid tumor(CD), low-grade malignacy and endocrine cell carcinoma(ECC). high-grade malignancy. Histological differential diagnosis between these two entities wasestablished.2. CD was suspected to be mainly derived from immature endocrine cells. ECC were hypothesized to derive from neoplastic endcrine cell in mucosal tubular adenocarcinoma, totipotential stem cell, CD, or immature endocrine cells. The first pathway was suspected to be most frequent, followed by the second.3. New classification of carcinoid tumors according to different ocurring sites wasestablished. Japanese patients have characteristic and incidence of distribution different from that of Europeans and Americans.4. Four cell lines were established from human esophageal, gastric and rectal ECC.They showed high levels of CK-BB (4 lines), low levels of aromatic L-amino-acid decarboxylase(2 lines) and NSE (3 lines), no amplification of C-myc, N-myc and L-myc (4lines) and expression of c-myc mRNA (2 lines).

在过去的两年中，这个特殊的项目，收集和分析日本胃肠道内分泌细胞肿瘤。胃肠道内分泌细胞肿瘤分为类癌（CD）、低度恶性肿瘤和内分泌细胞癌（ECC）。高度恶性肿瘤建立了两种肿瘤的组织学鉴别诊断. CD主要来源于未成熟的内分泌细胞。ECC可能来源于黏膜管状腺癌中的肿瘤性内分泌细胞、全能干细胞、CD或未成熟的内分泌细胞。第一条途径可能是最常见的，其次是第二条。根据类癌发生部位的不同，建立了新的分类。日本患者有不同于欧美患者的特点和发病率分布.从人食管、胃和直肠癌细胞中建立了4个细胞系，其中4个细胞系CK-BB高表达，2个细胞系芳香族L-氨基酸脱羧酶和NSE低表达，4个细胞系C-myc、N-myc和L-myc无扩增，2个细胞系c-myc mRNA表达。

项目成果

Iwafuchi M: "Histological Differential Diagnosis between regenerating epithelium and adenocarcinoma" Pathology and Clinical Medicine. 10(6). 638-644 (1992)

Iwafuchi M：“再生上皮和腺癌之间的组织学鉴别诊断”病理学和临床医学。

IWafuchi M: "Rule of macroscopic examination of surgically resected specimens" J Clin Surg. 48(1). 15-21 (1993)

IWafuchi M：“手术切除标本的宏观检查规则”J Clin Surg。

Noda Y: "Histologic follow-up of ampullary adenomas in patients with familial adenomatosis colli" Cancer. 70(7). 1847-1856 (1992)

Noda Y：“家族性腺瘤病患者壶腹腺瘤的组织学随访”癌症。

Ohta T: "Peutz-Jeghers polyps and gastrointestinal juvenile polyposis" Stomach and Intestine. 28(12). 1268-1278 (1993)

Ohta T：“黑斑息肉和胃肠道幼年性息肉病”胃和肠。

Oyama T.: "Diagnostic value of prolifevctive nkcleor antigen for myogenic tumor of the stomach" Gastroenterol Jpn. 28. 193-200 (1993)

Oyama T.：“增殖性NK细胞抗原对胃肌源性肿瘤的诊断价值”Gastroenterol Jpn。