The integrating mechanism of taste and smell;toward the improvement of ingesting functions for elderly people.

味觉与嗅觉的整合机制；致力于改善老年人的摄取功能。

• 批准号: 24792366
• 负责人: MIZOGUCHI Naoko
• 金额: $ 2.75万
• 依托单位: Meikai University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24792366/
• 关键词: 脳神経科学; 光学計測; 膜電位感受性色素; 島皮質; 味覚; 嗅覚; 脳・神経

Gustatory information processing could be modulated by olfaction. Not only gustation but also olfaction are processed in the insular cortex(IC). However, little information is available how these sensory inputs are integrated in the IC. The present study, aimed to examine the spatiotemporal dynamics of excitatory propagation in the IC induced by simultaneous stimulation of the parvicellular part of ventroposteromedial thalamic nucleus(VPMpc) and olfactory bulb(OB). We performed in vivo optical imaging with a voltage sensitive dye.The excitatory regions by stimulating the either OB or VPMpc were segregated except for the agranular region(AI). The excitatory signals in the AI showed an additive effect of simultaneous stimulations to the OB and VPMpc. Our data raise the possibility that a part of integration of gustatory and odor sense were carried out in AI. These results suggest that the AI may play a role in integrating the gustatory and olfactory information.

嗅觉处理可以通过嗅觉调节。不仅在岛状皮层（IC）中处理味道，而且还处理嗅觉。但是，几乎没有信息如何将这些感觉输入集成在IC中。本研究的目的是检查腹膜内侧丘脑核（VPMPC）和嗅球（OB）的同时刺激诱发的IC中兴奋性传播的时空动力学。我们用电压敏感的染料进行了体内光学成像。除了刺激OB或VPMPC刺激区域被隔离，除了植物区域（AI）。 AI中的兴奋信号表现出对OB和VPMPC的同时刺激的加成作用。我们的数据提出了一种可能性，即在AI中进行了味觉和气味意义的一部分。这些结果表明，AI可能在整合味觉和嗅觉信息中发挥作用。

项目成果

交連線維を介した左右島皮質間連絡様式の光学計測による解明

使用光学测量阐明左右岛皮质之间通过连合纤维的通信

• 发表时间: 2012
• 作者: 溝口尚子;小林真之;越川憲明
• 通讯作者: 越川憲明

無顆粒島皮質における味覚および嗅覚情報の統合, The integration of gustatory and olfactory information in the agranular insular cortex

无颗粒岛叶皮质中味觉和嗅觉信息的整合

• 发表时间: 2014
• 作者: 溝口尚子. 小林真之;村本和世
• 通讯作者: 村本和世

味覚中継核刺激によって誘発される島皮質での興奮伝播に対する嗅球刺激の効果Effects of olfactory bulb stimulation on the excitatory propagation in the insular cortex responding to the stimulation of the gustatory thalamic nucleus

嗅球刺激对岛皮层响应味觉丘脑核刺激的兴奋性传播的影响

• 发表时间: 2013
• 作者: 溝口尚子;小林真之;村本和世
• 通讯作者: 村本和世

Functional neuroimaging of aversive taste-related areas in the alert rat revealed by positron emission tomography

• DOI: 10.1002/jnr.23252
• 发表时间: 2013-10-01
• 期刊: JOURNAL OF NEUROSCIENCE RESEARCH
• 影响因子: 4.2
• 作者: Kobayashi, Masayuki;Cui, Yilong;Koshikawa, Noriaki
• 通讯作者: Koshikawa, Noriaki

日本大学歯学部薬理学講座 研究業績

日本大学牙科学院药理系研究成果