Evaluation of adsorbed protein film on joint prosthesis material by using electrochemical method

电化学方法评价关节假体材料上吸附蛋白膜

• 批准号: 24760122
• 负责人: NAKASHIMA Kazuhiro
• 金额: $ 2.91万
• 依托单位: Kyushu University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24760122/
• 关键词: 人工関節; 蛋白質; 境界潤滑膜; 電気化学測定; 吸着; 摩擦; 摩耗; 吸着膜; 低摩擦; 低摩耗; 吸着膜構造

Protein adsorbed film on joint prosthesis material affecting tribological property was evaluated by using electrochemical method. Albumin and gamma-globurin contained in natural cynovial fluid was selected for measurement. The combination of ultra-high molecular weight polyethylene (GUR1050) and CoCrMo alloy (ASTMF75) was employed. The potential between CoCrMo alloy and protein solution was measured to understand the behaviour of protein adsorption. Albumin was easily peeled off by shear force, it means the adsorption is weak. Gamma-globulin did not show desorption by shear force. Therefore, the difference of adsorption strength and stability is essence to form protein adsorption film.

用电化学方法研究了人工关节材料表面蛋白质吸附膜对摩擦学性能的影响。选择天然脑脊液中的白蛋白和γ-球蛋白进行测定。采用超高分子量聚乙烯（GUR 1050）和CoCrMo合金（ASTMF 75）的组合。测定了CoCrMo合金与蛋白质溶液之间的电位，以了解蛋白质的吸附行为。白蛋白很容易被剪切力剥离，说明吸附力很弱。γ-球蛋白未显示剪切力解吸。因此，吸附强度和稳定性的差异是形成蛋白质吸附膜的本质。

项目成果

Behavior of Adsorbed Albumin film on CoCrMo Alloy under In-situ observation

CoCrMo合金上吸附白蛋白膜的原位观察行为

• 发表时间: 2013
• 作者: Kazuhiro Nakashima;Yoshinori Sawae;Teruo Murakami;Stefano Mischler
• 通讯作者: Stefano Mischler

Protein Adsorption Film Observation by Using Electrochemical Method

电化学法观察蛋白质吸附膜

• 发表时间: 2014
• 作者: Kazuhiro Nakashima;Yoshinori Sawae;Susumu 2udo;Teruo Murakami
• 通讯作者: Teruo Murakami

摩擦挙動に寄与する蛋白質吸着膜の構造

有助于摩擦行为的蛋白质吸附膜结构

• 发表时间: 2013
• 作者: 中嶋和弘;村上輝夫
• 通讯作者: 村上輝夫

Effect of protein film on tribological property of joint prosthesis materials

蛋白质膜对关节假体材料摩擦学性能的影响

• 发表时间: 2013
• 作者: Chihara;T.;Izumi;T.;Seo;A.;矢地謙太郎,山田崇恭,吉野正人,松本敏郎,泉井一浩,西脇眞二;Kazuhiro Nakashima
• 通讯作者: Kazuhiro Nakashima

蛋白質吸着膜の摩擦負荷による変化のその場観察

蛋白质吸附膜摩擦负载引起的变化的原位观察

• 发表时间: 2013
• 作者: 中嶋和弘;工藤奨;村上輝夫;Stefano Mischler
• 通讯作者: Stefano Mischler