Preparation of novel iontophoresis electrodes by an electrolytic deposition method

电解沉积法制备新型离子电渗电极

• 批准号: 24760570
• 负责人: YOSHIOKA Tomohiko
• 金额: $ 2.91万
• 依托单位: Tokyo Institute of Technology
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24760570/
• 关键词: イオントフォレシス; 経皮吸収; DDS

This study is concerned with the preparation of novel iontophoresis electrodes delivering drugs through the skin into the body. The electrodes were prepared by electrochemical deposition of alginic acid gels on aluminum substrates. The deposited gels were tightly bonded on the substrates through the interaction between alginic acid and surface oxides of the substrates. The electrodes prepared loaded lidocaine electrostatically, and released the drug by applying external electric fields. Equivalent circuits for the electrode/rat skin system were analyzed, so that the use of AC iontophoresis is thought to be effective for transdermal drug delivery with the electrode prepared.

本研究是关于制备新型的离子电渗电极，通过皮肤将药物输送到体内。通过电化学沉积海藻酸凝胶在铝基板上制备电极。通过海藻酸与基底表面氧化物的相互作用，沉积的凝胶与基底紧密结合。制备的电极静电负载利多卡因，并通过施加外电场释放药物。对电极/大鼠皮肤系统的等效电路进行了分析，因此认为使用所制备的电极进行交流离子电渗可有效地用于经皮给药。

项目成果

AC Iontophoresis of Lidocaine with Alginic-Acid Gel Electrodes

使用海藻酸凝胶电极进行利多卡因交流离子电渗疗法

• 发表时间: 2013
• 作者: Tomoko Ebisawa;Katsuhiro Matsumoto;Atsuhi Nakajima;Haruka Haida;Shizuka Ando;Tomohiko Yoshioka;Toshiyuki Ikoma;Junzo Tanaka;and Haruhisa Fukayama
• 通讯作者: and Haruhisa Fukayama

Calcium Alginate Gels as Electrode Material for Iontophoresis of Lidocaine

海藻酸钙凝胶作为利多卡因离子导入电极材料

• 发表时间: 2013
• 作者: Tomoko Ebisawa;Katsuhiro Matsumoto;Astsushi Nakajima;Haruka Haida;Shizuka Ando;Tomohiko Yoshioka;Toshiyuki Ikoma;Junzo Tanaka;Haruhisa Fukayama
• 通讯作者: Haruhisa Fukayama

アルギン酸電極を用いたリドカインの交流イオントフォレーシス

使用藻酸盐电极进行利多卡因交流离子电渗疗法

• 发表时间: 2014
• 作者: 吉岡朋彦;生駒俊之;海老澤智子;松本勝洋;中島淳;灰田悠;安藤寧;脇田亮;深山治久;田中順三
• 通讯作者: 田中順三

Electro-responsive drug delivery of electrochemically deposited alginic acid gels on metals

金属上电化学沉积海藻酸凝胶的电响应药物输送

• 发表时间: 2012
• 作者: Tomohiko Yoshioka;Norio Saito;Toshiyuki Ikoma;Naoki Ohashi;Tomoko Ebisawa;Haruka Haida;Atsuhi Nakajima;Ryo Wakita;Haruhisa Fukayama;Masahiro Umino;and Junzo Tanaka
• 通讯作者: and Junzo Tanaka

Electrochemically deposited gels for transdermal drug delivery

用于透皮给药的电化学沉积凝胶

• 发表时间: 2012
• 作者: Tomohiko Yoshioka;Norio Saito;Toshiyuki Ikoma;Naoki Ohashi;Haruka Haida;Atsushi Nakajima;Ryo Wakita;Haruhisa Fukayama;Masahiro Umino;and Junzo Tanaka
• 通讯作者: and Junzo Tanaka