Preparation of novel iontophoresis electrodes by an electrolytic deposition method

这项研究涉及新型离子电渗电极的制备，通过皮肤将药物输送到体内。通过在铝基板上电化学沉积海藻酸凝胶来制备电极。通过海藻酸与基材表面氧化物之间的相互作用，沉积的凝胶紧密地结合在基材上。制备的电极静电负载利多卡因，并通过施加外部电场释放药物。对电极/大鼠皮肤系统的等效电路进行了分析，因此认为使用所制备的电极进行交流离子电渗疗法的经皮药物输送是有效的。

This study is concerned with the preparation of novel iontophoresis electrodes delivering drugs through the skin into the body. The electrodes were prepared by electrochemical deposition of alginic acid gels on aluminum substrates. The deposited gels were tightly bonded on the substrates through the interaction between alginic acid and surface oxides of the substrates. The electrodes prepared loaded lidocaine electrostatically, and released the drug by applying external electric fields. Equivalent circuits for the electrode/rat skin system were analyzed, so that the use of AC iontophoresis is thought to be effective for transdermal drug delivery with the electrode prepared.