The study of therapy for canine pituitary adenomas by 11beta-HSD inhibitor

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It was revealed that the effect of 11beta-HSD inhibitor on dogs was dose-dependent in this study. From the result of our study, it was suggested that ACTH secretion from pituitary was decreased by 11beta-HSD inhibitor in healthy dogs. Moreover, apparent side effects were not observed in the long term administration period of 11beta-HSD inhibitor. We have to research the effect of 11beta-HSD inhibitor on dogs with canine pituitary ACTH adenomas.In conclusion, we expect that there is possibility that 11beta-HSD inhibitor can be therapeutic drug for canine pituitary ACTH adenoma. Furthermore, we need to proceed this study for treatment of caine pituitary ACTH adenomas.