The study of therapy for canine pituitary adenomas by 11beta-HSD inhibitor

11β-HSD抑制剂治疗犬垂体腺瘤的研究

• 批准号: 24780315
• 负责人: TESHIMA Takahiro
• 金额: $ 2.91万
• 依托单位: Nippon Veterinary and Life Science University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24780315/
• 关键词: 下垂体; ACTH; クッシング症候群; 11β-HSD

It was revealed that the effect of 11beta-HSD inhibitor on dogs was dose-dependent in this study. From the result of our study, it was suggested that ACTH secretion from pituitary was decreased by 11beta-HSD inhibitor in healthy dogs. Moreover, apparent side effects were not observed in the long term administration period of 11beta-HSD inhibitor. We have to research the effect of 11beta-HSD inhibitor on dogs with canine pituitary ACTH adenomas.In conclusion, we expect that there is possibility that 11beta-HSD inhibitor can be therapeutic drug for canine pituitary ACTH adenoma. Furthermore, we need to proceed this study for treatment of caine pituitary ACTH adenomas.

本研究显示11β - hsd抑制剂对犬的作用呈剂量依赖性。从我们的研究结果来看，我们认为11β - hsd抑制剂可以降低健康犬垂体ACTH的分泌。此外，在长期给药期间未观察到明显的副作用。我们需要研究11β - hsd抑制剂对犬垂体ACTH腺瘤的影响。综上所述，我们期望11β - hsd抑制剂有可能成为犬垂体ACTH腺瘤的治疗药物。此外，我们还需要进一步研究垂体ACTH腺瘤的治疗方法。

项目成果

Expression of 11β-hydroxysteroid dehydrogenase isoforms in canine adrenal glands treated with trilostane.

用曲洛斯坦治疗的犬肾上腺中 11β-羟基类固醇脱氢酶亚型的表达。

• DOI: 10.1016/j.tvjl.2014.03.022
• 发表时间: 2014
• 期刊: Veterinary Journal
• 影响因子: 2.2
• 作者: Teshima T;Matsumoto H;Kumagai T;Kurano M;Koyama H.
• 通讯作者: Koyama H.