Molecular mechanisms of permeability transition revealed using quantitative proteomic analysis

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Mitochondrial permeability transition triggers subsequent steps of apoptosis. To understand the molecular mechanisms of permeability transition, we here performed the quantitative proteomic analysis to identify the regulatory proteins for permeability transition. As a result, we found some candidate proteins, which were oxidized when a permeability transition inducer was added to isolated mitochondria. We will examine whether the proteins are related to the regulation of permeability transition.