Brain pericytes induce the brain inflammation that derived from chronic peripheral inflammation in diabetic mellitus via PAR-1 signal

脑周细胞通过PAR-1信号诱导糖尿病慢性周围炎症引起的脑炎症

• 批准号: 24790102
• 负责人: MACHIDA Takashi
• 金额: $ 2.83万
• 依托单位: Fukuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790102/
• 关键词: 薬理学; 脳内炎症; 糖尿病; 脳ペリサイト; トロンビン

In diabetic mellitus, inflammation is observed in the brain as well as the peripheral and contributes to the pathogenesis of diabetic cognitive dysfunction. This study aimed to clarify the involvement of thrombin-responsive brain pericytes in the propagation mechanism of inflammation from the peripheral to the brain. Increase the amount of thrombin was observed in the brain of high-fat diet induced obesity and glucose-intolerance model mouse. Further, thrombin-treated brain pericytes enhanced the permeability of the blood-brain barrier, and released matrix metalloproteinase-9. These results suggest that thrombin-responsive brain pericytes have an important role in the formation of brain inflammation in diabetic mellitus.

在糖尿病中，炎症在大脑和外周都可以观察到，并参与了糖尿病认知功能障碍的发病机制。本研究旨在阐明凝血酶反应性脑周细胞参与炎症从外周到脑的传播机制。高脂饮食诱导的肥胖和糖耐量减低模型小鼠脑内凝血酶含量增加。此外，凝血酶处理的脑周细胞增加了血脑屏障的通透性，并释放了基质金属蛋白酶-9。这些结果提示凝血酶反应性脑周细胞在糖尿病脑炎症的形成中起重要作用。

项目成果

トロンビン誘発性血液脳関門障害における脳ペリサイトの関与

脑周细胞参与凝血酶诱导的血脑屏障功能障碍

• 发表时间: 2013
• 作者: 町田崇;道具伸也;高田芙友子;松本純一;竹之下恭代;山内淳史;片岡泰文
• 通讯作者: 片岡泰文