Development of siRNA based anti Nidovirus drug against mosquito

基于siRNA的抗蚊子Nidovirus药物的开发

• 批准号: 24790134
• 负责人: SATHO Tomomitsu
• 金额: $ 2.66万
• 依托单位: Fukuoka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790134/
• 关键词: コガタアカイエカ; ニドウイルス; メソニウイルス; シマカ

Dak Nong Virsu (DKNV) was isolated from Culex tritaeniorhynchus collected in Vietnam. Electron microscopic analysis showed that DKNV is enveloped, spherical virus with an diameter of 80nm. The complete genome sequence of DKNV was 20256bp and its genome appeared to contain at least seven ORFs. DKNV RdRp sequence was most similar to that of the members of the species Alphamesonivirus1 (Cavally virus and Nam Dinh virus) in the genus Alphamesonivirus of the family Mesoniviridase.

Dak Nong Virsu（DKNV）是从越南采集的三带喙库蚊（Culex tritaeniorhynchus）中分离到的病毒。电镜分析表明，DKNV为有囊膜的球形病毒，直径约80nm。DKNV的全基因组序列为20256bp，基因组中至少含有7个开放阅读框。DKNV RdRp序列与中脊病毒科Alphamesonivirus属中的Alphamesonivirus 1（Cavally病毒和南定病毒）的成员最相似。

项目成果

Update on Temporal and Spatial Abundance of Dengue Vectors in Penang, Malaysia

马来西亚槟城登革热媒介时空丰度的最新情况

• DOI: 10.2987/11-6220r.1
• 发表时间: 2012
• 期刊: Infection & Chemotherapy
• 影响因子: 4.2
• 作者: Rahman G. M. Saifur;Ahmad Abu Hassan;H. Dieng;H. Ahmad;Md Rawi Che Salmah;T. Satho;A. Saad;R. M. Vargas
• 通讯作者: R. M. Vargas

Characterization of Dak Nong virus, an insect nidovirus isolated from Culex mosquitoes in Vietnam.

• DOI: 10.1007/s00705-013-1741-4
• 发表时间: 2013-11
• 期刊: Archives of virology
• 影响因子: 2.7
• 作者: Kuwata R;Satho T;Isawa H;Yen NT;Phong TV;Nga PT;Kurashige T;Hiramatsu Y;Fukumitsu Y;Hoshino K;Sasaki T;Kobayashi M;Mizutani T;Sawabe K
• 通讯作者: Sawabe K

Elevation of dopamine level reduces host-seeking activity in the adult female mosquito Aedes albopictus.

• DOI: 10.1186/1756-3305-5-92
• 发表时间: 2012-05-10
• 期刊: Parasites & vectors
• 影响因子: 3.2
• 作者: Fukumitsu Y;Irie K;Satho T;Aonuma H;Dieng H;Ahmad AH;Nakashima Y;Mishima K;Kashige N;Miake F
• 通讯作者: Miake F

ベトナム捕集蚊より分離された新規ニドウイルスの性状解析

从越南收集的蚊子中分离出的新型巢状病毒的特征

• 发表时间: 2013
• 作者: 鍬田龍星、佐藤朝光、伊澤晴彦、Yen;Nguyen Thi、Phong;Tran Vu、Nga;Phan Thi、倉重友和、平松征洋、福光由起、星野啓太、佐々木年則、水谷哲也、前田健、小林睦生、沢辺京子
• 通讯作者: Phan Thi、倉重友和、平松征洋、福光由起、星野啓太、佐々木年則、水谷哲也、前田健、小林睦生、沢辺京子

A decrease of host-seeking behavior in virgin female appears without elevation of dopamine levels in the adult mosquito Aede albopictus

白纹伊蚊成虫的多巴胺水平没有升高，但处女雌性的寻找宿主行为却有所减少

• 发表时间: 2012
• 作者: 福光 由起;入江 圭一;佐藤 朝光;中島 幸彦;三島 健一;鹿志毛 信広;見明 史雄
• 通讯作者: 見明 史雄