Study on role of protein nitrosylation in the nitric oxide-mediated prevention of asthma

蛋白质亚硝基化在一氧化氮介导的哮喘预防中的作用研究

• 批准号: 24790587
• 负责人: TAKAHASHI Hidekazu
• 金额: $ 2.83万
• 依托单位: Yamaguchi University (2013)Okayama University (2012)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24790587/
• 关键词: 予防医学; 喘息; 一酸化窒素; マウス; ニトロソ化タンパク質

The goal of this study is to develop a novel method to prevent asthma. It is known that nitric oxide plays key roles in asthma. Nitric oxide is known to function as a bronchodilator. However, the detailed mechanisms of action remain incompletely understood. This study examined, using a murine model of asthma, the changes in the concentrations of nitric oxide-modified proteins and other nitric oxide-derived small molecules. Nitric oxide-modified proteins and other nitric oxide-derived molecules were rather increased in asthma.

这项研究的目的是开发一种新的方法来预防哮喘。众所周知，一氧化氮在哮喘中起着关键作用。已知一氧化氮具有支气管扩张剂的作用。然而，详细的作用机制仍不完全清楚。本研究使用小鼠哮喘模型检测了一氧化氮修饰蛋白和其他一氧化氮衍生小分子浓度的变化。一氧化氮修饰的蛋白质和其他一氧化氮衍生分子在哮喘中相当增加。

项目成果

山口大学医学系研究科環境統御健康医学分野

山口大学医学研究科环境管理与健康医学系

Anti-inflammatory Effect of Arginase Inhibitor and Corticosteroid on Airway Allergic Reactions in a Dermatophogoides farinae-induced NC/Nga Mouse Model

• DOI: 10.1007/s10753-012-9529-3
• 发表时间: 2013-02-01
• 期刊: INFLAMMATION
• 影响因子: 5.1
• 作者: Ogino, Keiki;Kubo, Masayuki;Fujikura, Yoshihisa
• 通讯作者: Fujikura, Yoshihisa