Development of MEG-based neuroprosthetic arm and examination of cortical reorganization caused by reconstruction of motor function

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In this research, a novel neuroprosthetic arm was developed by acquiring neuromagnetic signals from clinical magnetoencepharography system and analyzing the data to extract motor information online. This system allowed some paralyzed patients to control the arm only by intending to move their paralyzed hand. Actually, the developed neuroprosthesis was applied for the patients with severe paralysis due to brachial plexus root avulsion, amyotrophic lateral sclerosis, stroke and cerebral palsy. The MEG signals were analyzed to extract motor information when the patients intended to move their paralyzed hand. Moreover, after training to use this neuroprosthesis, the brain activities of the patients were modulated to be appropriate for information extraction. These plastic changes suggests that the novel system has potential to be applied for rehabilitation of the severely paralyzed patients.