Development of bidirectional brain-machine interface using electrocorticogram to restore motor functions of arms for paralyzed patients

利用皮层电图开发双向脑机接口以恢复瘫痪患者手臂的运动功能

• 批准号: 22700435
• 负责人: YANAGISAWA Takufumi
• 金额: $ 2.75万
• 依托单位: Osaka University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2010
• 资助国家: 日本
• 起止时间: 2010 至 2011
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-22700435/
• 关键词: ブレインマシーンインターフェイス; Brain-machine interface; 感覚フィードバック; 皮質脳波; 上肢運動機能再建; 電動義手; Brain-machlne interface

In this study, we have developed a bidirectional brain-machine interface to operate a prosthetic arm with tactile sensor using the electrocorticogram(ECoG) recorded by the electrodes implanted on human sensorimotor cortices. Some severely paralyzed patients due to stroke or trauma were shown to be able to operate the prosthetic arm only using their ECoG signals by imaging some movements of their paralyzed limbs. The patients operated the prosthetic arm to manipulate some objects by grasping and releasing. Furthermore, we have developed a prosthetic arm to be controlled by signals of magnetoencephalogram(MEG).

在这项研究中，我们开发了一种双向脑机接口，利用植入人体感觉运动皮层的电极记录的皮层电图（ECoG）来操作带有触觉传感器的假肢。一些因中风或外伤而严重瘫痪的患者仅使用 ECoG 信号，通过对瘫痪肢体的一些运动进行成像来操作假肢。患者操作假肢，通过抓握和释放来操纵一些物体。此外，我们还开发了一种由脑磁图（MEG）信号控制的假肢。

项目成果

Real-time control of a prosthetic hand using human electrocorticograms

使用人体皮层电图实时控制假手

• 发表时间: 2011
• 期刊: J Neurosurg
• 影响因子: 4.1
• 作者: Yanagisawa T;Hirata M;Saitoh Y;Goto T;Kishima H;Fukuma R;Yokoi H;Kamitani Y;Yoshimine T
• 通讯作者: Yoshimine T

脳損傷後の皮質脳波変化の定量的解析とBMIへの応用

脑损伤后皮质脑电图变化的定量分析及其在BMI中的应用

• 发表时间: 2011
• 作者: Hirata M;Matsushita K;Yanagisawa T;Goto T;Morris S;Yokoi H;Suzuki T;Yoshida T;Sato F;Sakura O;Kamitani Y;Yoshimine T;Takufumi Yanagisawa;Takufumi Yanagisawa;柳澤琢史;柳澤琢史;柳澤琢史
• 通讯作者: 柳澤琢史

Gamma amplitude coupled with alpha phase represents motor

伽马振幅与阿尔法相位相结合代表运动

• 发表时间: 2011
• 作者: Hirata M;Matsushita K;Yanagisawa T;Goto T;Morris S;Yokoi H;Suzuki T;Yoshida T;Sato F;Sakura O;Kamitani Y;Yoshimine T;Takufumi Yanagisawa
• 通讯作者: Takufumi Yanagisawa

Electrocorticographic Control of a Prosthetic Arm in Paralyzed Patients

• DOI: 10.1002/ana.22613
• 发表时间: 2012-03-01
• 期刊: ANNALS OF NEUROLOGY
• 影响因子: 11.2
• 作者: Yanagisawa, Takufumi;Hirata, Masayuki;Yoshimine, Toshiki
• 通讯作者: Yoshimine, Toshiki

Motor Restoration based on the Brain Machine Interface using Brain Surface Elec- trodes: Real Time Robot Control and a Fully-implantable Wireless Sys- tem

基于使用脑表面电极的脑机接口的运动恢复：实时机器人控制和完全植入的无线系统

• DOI: 10.1163/156855311x614581
• 发表时间: 2011
• 期刊: Advanced Robotics
• 影响因子: 2
• 作者: Masayuki Hirata;Kojiro Matsushita;Takuhumi Yanagisawa;Tetsu Goto;Shayne Morris;Hiroshi Yokoi;Taka- fumi Suzuki;Tekeshi Yoshida;Fumi- hiro Sato;Osamu Sakura;Yasuyuki Kamitani;Toshiki Yoshimine
• 通讯作者: Toshiki Yoshimine