Surface properties of DNA brush layers and their applications

一般来说，即使低于熔化温度，双链DNA （dsDNA）也会经历微小的热波动，短暂地破坏氢键和脱离碱基（所谓的“呼吸”）。位于末端的碱基对比位于dsDNA链中部的碱基对表现出更高的呼吸频率。dsDNA的这种构象动力学在包括DNA转录和复制在内的各种生物过程中起着重要作用。在这项研究中，我们发现由dsDNA组成的电刷层的表面性能在很大程度上取决于它们的末端动力学。

In general, double-stranded DNA (dsDNA) undergoes the small thermal fluctuations that transiently break hydrogen bonds and unstuck bases (so-called "breathing") even below the melting temperature. A base pair that is located at the terminal exhibits a higher frequency of breathing than those in the middle part of dsDNA strand. Such conformational dynamics of dsDNA play important roles in various biological processes, including DNA transcription and replication. In this study, we found that the surface properties of a brush layer composed of dsDNA largely depend on their terminal dynamics.