Surface properties of DNA brush layers and their applications

一般来说，双链DNA（dsDNA）会经历微小的热波动，即使在熔点以下也会短暂地破坏氢键并解开碱基（所谓的“呼吸”）。位于末端的碱基对比位于dsDNA链中间部分的碱基对表现出更高的呼吸频率。这种双链DNA的构象动力学在包括DNA转录和复制在内的各种生物过程中起着重要作用。在这项研究中，我们发现，刷层组成的dsDNA的表面性质在很大程度上取决于其终端动力学。

In general, double-stranded DNA (dsDNA) undergoes the small thermal fluctuations that transiently break hydrogen bonds and unstuck bases (so-called "breathing") even below the melting temperature. A base pair that is located at the terminal exhibits a higher frequency of breathing than those in the middle part of dsDNA strand. Such conformational dynamics of dsDNA play important roles in various biological processes, including DNA transcription and replication. In this study, we found that the surface properties of a brush layer composed of dsDNA largely depend on their terminal dynamics.