Creation of hybrid-type carrier from lipid and peptide for functional nutraceuticals

从脂质和肽中创建用于功能性营养保健品的混合型载体

• 批准号: 24700823
• 负责人: OHTA Akio
• 金额: $ 2.25万
• 依托单位: Kanazawa University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2012
• 资助国家: 日本
• 起止时间: 2012-04-01 至 2014-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-24700823/
• 关键词: 特殊栄養食品; 分子集合体; 脂質; ペプチド; カゼイン; リポソーム; 抗酸化物質

Both casein and lecithin are natural food products and also essential nutraceuticals. Furthermore, because of their properties, caseins and liposomes are used to deliver medicines and nutraceuticals. Genistein is one of several known plant-derived isoflavons; is particularly plentiful in soybeans. The antioxidant and phytoestrogen properties of genistein are associated with the prevention of hormone-dependent cancers. In this study, caseinate and liposomes were used as a model casein solution as a material for encapsulating genistein. Peptides generated from the digestion of milk proteins are reported to have antioxidative activities. Then it is expected that genistein will has synergisms effect in antioxidant capacity with caseinate, as it dissolved in the caseinate system. Although there is no synergisms effect in liposome system solubilizing genistein, the phospholipid liposome is able to include tremendously many genistein molecules. These can be complementary to each other.

酪蛋白和卵磷脂都是天然食品，也是必不可少的营养品。此外，由于其性质，酪蛋白和脂质体用于递送药物和营养品。染料木黄酮是几种已知的植物来源的染料之一;在大豆中特别丰富。染料木黄酮的抗氧化剂和植物雌激素特性与预防乳腺癌相关。 在这项研究中，酪蛋白酸盐和脂质体被用作模型酪蛋白溶液作为包封染料木素的材料。 据报道，乳蛋白消化产生的肽具有抗氧化活性。因此，染料木素在酪蛋白酸体系中的溶解性与酪蛋白酸具有协同抗氧化作用。脂质体体系对染料木黄酮的增溶作用不存在协同效应，但磷脂脂质体能够包合大量的染料木黄酮分子。 它们可以相互补充。

项目成果

カルシウムイオンを介したリン脂質ベシクルへのカゼインの集積

酪蛋白通过钙离子积累到磷脂囊泡中

• 发表时间: 2013
• 作者: ANJANI Gemala;OHTA Akio;YASUHARA Kazuma;ASAKAWA Tsuyoshi;Anjani Gemala,太田明雄,浅川毅;山本隼也,太田明雄,浅川毅
• 通讯作者: 山本隼也,太田明雄,浅川毅

Antioxidation Capacity of Genistein in Caseinate System

酪蛋白酸盐体系中金雀异黄酮的抗氧化能力

• 发表时间: 2013
• 作者: ANJANI Gemala;OHTA Akio;YASUHARA Kazuma;ASAKAWA Tsuyoshi;Anjani Gemala,太田明雄,浅川毅
• 通讯作者: Anjani Gemala,太田明雄,浅川毅