Possibility of the whole body supply of hydrogen formed in large intestine and the nutritional role

本研究的目的是阐明一部分来自大肠的氢转移到全身各器官并提供氢有助于减轻全身的氧化应激，如肥胖。首先我们分析了来自大肠的氢的生物分布，发现门静脉血、肝脏、肾周脂肪、附睾脂肪中的氢浓度升高。此外，我们提出，它不能只通过门静脉的过程中提供氢到所有的器官。我们检查了遗传性肥胖模型小鼠的遗传背景，导致肥胖的影响，氢大肠产生由于果聚糖比野生型小鼠更强，并阐明了它是指导。

The aim of this study is to clarify that a part of hydrogen derived from large intestine moved to the organs of the whole body and supplied hydrogen contributed to reduce the oxidation stress of whole bodies such as the obesity.At first we analyzed biodistribution of hydrogen derived from large intestine and found that hydrogen concentration in portal blood, liver, perirenal fat, epididimal fat rose. In addition, we proposed that it could not supply hydrogen to all organs only by the course through the portal vein.We examined the influence that a genetic background to cause the obesity of the hereditary obesity model mouse gave for hydrogen and hydrogen large intestine generation due to fructan was stronger than a wild type mouse and clarified that it was guided.