Characterization of the oncogenic activity of TRB3 by regulating p53 activation

TRB3最初被确定为响应内质网应激的激酶样分子。虽然TRB3具有底物结合结构域，但缺乏用于蛋白质磷酸化的公认氨基酸。因此，TRB3被认为是一种支架蛋白，对各种信号转导进行正向和负向调节。在这个项目中，我们已经证明了TRB3与p53相互作用并减弱了p53的生物学功能。此外，TRB3是细胞暴露于内质网应激时的一种新的检查点调节因子。

TRB3 is originally identified as a kinase-like molecule in response to ER stress. While TRB3 has the substrate-binding domain, the consensus amino acids for protein phosphorylation are missing. Therefore, TRB3 is believed to act as a scaffold protein regulating various signal transducers positively and negatively. In this project, we have demonstrated that TRB3 interacts with p53 and attenuates the biological functions of p53. Also, it is revealed that TRB3 is a novel checkpoint reguators when cells are exposed to ER stress.