Characterization of the oncogenic activity of TRB3 by regulating p53 activation

TRB3最初被鉴定为响应ER应激的激酶样分子。虽然TRB3具有底物结合结构域，但蛋白磷酸化的共有氨基酸缺失。因此，TRB3被认为是一种支架蛋白，正性和负性地调节各种信号转导。在这个项目中，我们已经证明TRB3与p53相互作用并减弱p53的生物学功能。此外，TRB 3是一种新的检查点调节剂，当细胞暴露于ER应激时。

TRB3 is originally identified as a kinase-like molecule in response to ER stress. While TRB3 has the substrate-binding domain, the consensus amino acids for protein phosphorylation are missing. Therefore, TRB3 is believed to act as a scaffold protein regulating various signal transducers positively and negatively. In this project, we have demonstrated that TRB3 interacts with p53 and attenuates the biological functions of p53. Also, it is revealed that TRB3 is a novel checkpoint reguators when cells are exposed to ER stress.