Investigation of adhesion mechanism of plant-derived adhesives

为了实现生物医学领域的植物源粘合剂的实际应用，我们设定了以下目标。1）为了阐明邻苯二酚基团的相互作用机理，本课题利用原子力显微镜（AFM）进行了研究，阐明了羟基数目对相互作用力的影响。并对邻苯二酚基团与部分氧化的吸附剂进行了量子化学计算。结果表明，邻苯二酚的羟基与吸附剂中的氧原子作用，形成较强的氢键。2）阐明植物源胶粘剂的生物亲和性。在本研究课题中，我们使用了牙髓细胞，这是人体中最敏感的细胞。我们已经阐明了我们的植物源粘合剂甚至不影响牙髓细胞及其专业化。我们得出结论，我们的植物源粘合剂的单体是适当的选择和合成。我们的研究结果承诺，我们的植物来源的粘合剂可以作为生物粘合剂在我们身体的任何地方使用。

We set following goals to achieve practical application of our plant-derived adhesives for biomedical fields. 1)To clarify interaction mechanism of catechol group.This research topic was carried out using AFM and we clarified that number of hydroxyl group significantly affect interaction force. We also carried out quantum chemical calculation between catechol group and partially oxidized adherent. It was found that hydroxyl groups of catechol act onto oxygen of adherent and formed strong hydrogen bonding. 2)To clarify bio-affinities of plant-derived adhesives. In this research topic, we used pulpal cell which is the most sensitive cell in human body. We have clarified our plant-derived adhesive never affect even to pulpal cells and their specializations.We concluded monomers of our plant-derived adhesive were adequately selected and synthesized. Our results promise that our plant-derived adhesives can be used in our body everywhere as bio-adhesive.