Studies on the mechanisms involved in the host range restriction of influenza A viruses

甲型流感病毒宿主范围限制机制研究

• 批准号: 25460581
• 负责人: Imai Masaki
• 金额: $ 3.33万
• 依托单位: The University of Tokyo (2015)Iwate University (2013-2014)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25460581/
• 关键词: 鳥インフルエンザウイルス; ヘマグルチニン（HA）蛋白質; 安定性; レセプター特異性; 膜融合活性; 感染性; 熱安定性; 酸性pH; 季節性インフルエンザウイルス; 構造安定性

项目成果

Circulating avian influenza viruses closely related to the 1918 virus have pandemic potential.

• DOI: 10.1016/j.chom.2014.05.006
• 发表时间: 2014-06-11
• 期刊: Cell host & microbe
• 影响因子: 30.3
• 作者: Watanabe T;Zhong G;Russell CA;Nakajima N;Hatta M;Hanson A;McBride R;Burke DF;Takahashi K;Fukuyama S;Tomita Y;Maher EA;Watanabe S;Imai M;Neumann G;Hasegawa H;Paulson JC;Smith DJ;Kawaoka Y
• 通讯作者: Kawaoka Y

Selection on haemagglutinin imposes a bottleneck during mammalian transmission of reassortant H5N1 influenza viruses.

• DOI: 10.1038/ncomms3636
• 发表时间: 2013
• 期刊: NATURE COMMUNICATIONS
• 影响因子: 16.6
• 作者: Wilker, Peter R.;Dinis, Jorge M.;Starrett, Gabriel;Imai, Masaki;Hatta, Masato;Nelson, Chase W.;O'Connor, David H.;Hughes, Austin L.;Neumann, Gabriele;Kawaoka, Yoshihiro;Friedrich, Thomas C.
• 通讯作者: Friedrich, Thomas C.

Novel residues in avian influenza virus PB2 protein affect virulence in mammalian hosts.

• DOI: 10.1038/ncomms6021
• 发表时间: 2014-10-07
• 期刊: Nature communications
• 影响因子: 16.6
• 作者: Fan S;Hatta M;Kim JH;Halfmann P;Imai M;Macken CA;Le MQ;Nguyen T;Neumann G;Kawaoka Y
• 通讯作者: Kawaoka Y

Characterization of H7N9 influenza A viruses isolated from humans.

• DOI: 10.1038/nature12392
• 发表时间: 2013-09-26
• 期刊: NATURE
• 影响因子: 64.8
• 作者: Watanabe, Tokiko;Kiso, Maki;Fukuyama, Satoshi;Nakajima, Noriko;Imai, Masaki;Yamada, Shinya;Murakami, Shin;Yamayoshi, Seiya;Iwatsuki-Horimoto, Kiyoko;Sakoda, Yoshihiro;Takashita, Emi;McBride, Ryan;Noda, Takeshi;Hatta, Masato;Imai, Hirotaka;Zhao, Dongming;Kishida, Noriko;Shirakura, Masayuki;de Vries, Robert P.;Shichinohe, Shintaro;Okamatsu, Masatoshi;Tamura, Tomokazu;Tomita, Yuriko;Fujimoto, Naomi;Goto, Kazue;Katsura, Hiroaki;Kawakami, Eiryo;Ishikawa, Izumi;Watanabe, Shinji;Ito, Mutsumi;Sakai-Tagawa, Yuko;Sugita, Yukihiko;Uraki, Ryuta;Yamaji, Reina;Eisfeld, Amie J.;Zhong, Gongxun;Fan, Shufang;Ping, Jihui;Maher, Eileen A.;Hanson, Anthony;Uchida, Yuko;Saito, Takehiko;Ozawa, Makoto;Neumann, Gabriele;Kida, Hiroshi;Odagiri, Takato;Paulson, James C.;Hasegawa, Hideki;Tashiro, Masato;Kawaoka, Yoshihiro
• 通讯作者: Kawaoka, Yoshihiro

Transmission of influenza A/H5N1 viruses in mammals.

• DOI: 10.1016/j.virusres.2013.07.017
• 发表时间: 2013-12-05
• 期刊: Virus research
• 影响因子: 5
• 作者: Imai M;Herfst S;Sorrell EM;Schrauwen EJ;Linster M;De Graaf M;Fouchier RA;Kawaoka Y
• 通讯作者: Kawaoka Y