Discovery of new insulin-resistance marker which determines the effect of IFN for chronic hepatitis C

发现新的胰岛素抵抗标志物，决定干扰素对慢性丙型肝炎的作用

• 批准号: 25461012
• 负责人: Ohkoshi Shogo
• 金额: $ 2.91万
• 依托单位: The Nippon Dental University (2014-2015)Showa University (2013)
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2016-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25461012/
• 关键词: HCV; RBP-4; Peg-IFN; インスリン抵抗性; IFN; Insulin抵抗性; C型慢性肝炎; インターフェロン; リバビリン; RBP4; 肝脂肪化

项目成果

Hepatitis B virus X stimulates redox signaling through activation of ataxia telangiectasia mutated kinase.

• 发表时间: 2014-04
• 期刊: International journal of clinical and experimental pathology
• 影响因子: 1.4
• 作者: Y. Matsuda;Ayumi Sanpei;T. Wakai;Masayuki Kubota;Mami Osawa;Y. Hirose;J. Sakata;Takashi Kobayashi;Shun Fujimaki;M. Takamura;S. Yamagiwa;M. Yano;S. Ohkoshi;Y. Aoyagi

Retinol binding protein 4, an insulin-resistance marker, induces interferon resistance in chronic hepatitis C.

视黄醇结合蛋白 4 是一种胰岛素抵抗标记物，可诱导慢性丙型肝炎的干扰素抵抗。

• 发表时间: 2016
• 期刊: Hepatogastroenterology
• 作者: Takahashi H;Ohkoshi S; Matsuda Y;et al.
• 通讯作者: et al.

Retinol binding protein 4, an insulin- resistance marker, induces interferon resistance in chronic hepatitis C

视黄醇结合蛋白 4（一种胰岛素抵抗标记物）可诱导慢性丙型肝炎的干扰素抵抗

• 发表时间: 2015
• 期刊: Hepatogastroenterology
• 作者: Hiromichi Takahashi;Shogo Ohkoshi;Masahiko Yano;Satoshi Yamagiwa;Masanori Ikeda;Nobuyuki Kato; Yasunobu Matsuda;Yutaka Aoyagi
• 通讯作者: Yutaka Aoyagi

Contributions of transgenic mouse studies on the research of hepatitis B virus and hepatitis C virus-induced hepatocarcinogenesis.

转基因小鼠研究对乙型肝炎病毒和丙型肝炎病毒诱发肝癌研究的贡献。

• DOI: 10.4254/wjh.v7.i28.2834
• 发表时间: 2015
• 期刊: World J Hepatol
• 影响因子: 2.4
• 作者: Ohkoshi S;Hirono H;Watanabe K;et al.
• 通讯作者: et al.

Double staining with crystal violet and methylene blue is appropriate for colonic endocytoscopy: an in vivo prospective pilot study.

• DOI: 10.1111/den.12164
• 发表时间: 2014-05
• 期刊: Digestive endoscopy : official journal of the Japan Gastroenterological Endoscopy Society
• 作者: Ichimasa K;Kudo SE;Mori Y;Wakamura K;Ikehara N;Kutsukawa M;Takeda K;Misawa M;Kudo T;Miyachi H;Yamamura F;Ohkoshi S;Hamatani S;Inoue H
• 通讯作者: Inoue H