Experimental study of the interaction of near-wall flow with flexible polymers at micro-scale

微尺度近壁流与柔性聚合物相互作用的实验研究

• 批准号: 5425080
• 负责人: Professor Dr.-Ing. Wolfgang Schröder
• 金额: --
• 依托单位: Lehrstuhl für Strömungslehre und Aerodynamisches Institut (AIA)
• 依托单位国家: 德国
• 项目类别: Priority Programmes
• 财政年份: 2004
• 资助国家: 德国
• 起止时间: 2003-12-31 至 2009-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5425080?language=en
• 关键词: Experimental; study; interaction; near; wall

The proposed project is part of a cooperation of the Institute of Aerodynamics, RWTH Aachen with the research group of Prof. Spatz, Univ. Heidelberg and Prof. Zimmermann, Univ. Saarbrücken. The aim of the experimental study is the detailed analysis of the interaction of near-wall flow with polymers anchored on top of flexible micropillars in a defined shear flow. The micro-fabricated elastomeric pillars are used to position the macromolecules in a defined wall distance and to measure the deformation forces of the polymers via the pillar bending. The interaction of the micro-pillars and the anchored polymers with the flow is studied in detail using Particle-Image Velocimetry measurements at microscale (micro-PIV) and timelapse microscopy. The experimental study allows a detailed analysis how the flow field deforms the tethered polymers and how the flow field is modified by the presence of the polymers, both issues of which are theoretically studied by Prof. Zimmermann, one of the cooperating partners. In addition, the detailed knowledge of the flow field is important to understand shear induced transport and biochemical reactions investigated with a similar device by the group of Prof. Spatz. They use the micropillar surface as a force measurement device for the study of biochemical reactions on networks of biomolecules.

该项目是亚琛工业大学空气动力学研究所与德国大学 Spatz 教授研究小组合作的一部分。海德堡和 Zimmermann 教授，大学。萨尔布吕肯。实验研究的目的是详细分析近壁流与固定在限定剪切流中柔性微柱顶部的聚合物的相互作用。微制造的弹性柱用于将大分子定位在限定的壁距离内，并通过柱弯曲来测量聚合物的变形力。使用微尺度粒子图像测速 (micro-PIV) 和延时显微镜详细研究了微柱和锚定聚合物与流动的相互作用。该实验研究可以详细分析流场如何使系留聚合物变形以及流场如何因聚合物的存在而改变，这两个问题都是由合作伙伴之一的Zimmermann教授从理论上进行了研究。此外，流场的详细知识对于理解 Spatz 教授小组使用类似设备研究的剪切诱导传输和生化反应非常重要。他们使用微柱表面作为力测量装置来研究生物分子网络上的生化反应。