The mechanism of autocrine and paracrine growth promotion of CML cells

CML细胞自分泌和旁分泌促生长机制

• 批准号: 25860792
• 负责人: SUGITANI Mio
• 金额: $ 2.58万
• 依托单位: Kyoto Prefectural University of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Young Scientists (B)
• 财政年份: 2013
• 资助国家: 日本
• 起止时间: 2013-04-01 至 2015-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-25860792/
• 关键词: 慢性骨髄性白血病; Galectin-3; 骨髄腫瘍環境由来治療抵抗性; オートクライン・パラクライン; 幹細胞能

项目成果

PVT-1-NSMCE2 fusion gene enhances BCL-XL expression and drug resistance in leukemic cells.

PVT-1-NSMCE2融合基因增强白血病细胞中BCL-XL的表达和耐药性。

• 发表时间: 2014
• 作者: Chinen Y;Sakamoto N;Nagoshi H;Taki T;Kobayashi S;Nishida K;Maegawa S;Kiyota M;Mizutani S;Shimura Y;Sugitani M;Kobayashi T;Matsumoto Y;Horiike S;Kuroda J;Taniwaki M.
• 通讯作者: Taniwaki M.

Suppression of SERPINA1-albumin complex formation by galectin-3 overexpression leads to paracrine growth promotion of chronic myelogenous leukemia cells.

• DOI: 10.1016/j.leukres.2013.07.026
• 发表时间: 2014
• 期刊: Leukemia research
• 影响因子: 2.7
• 作者: Ryuko Nakayama;J. Kuroda;Nobuko Taniyama;Mio Yamamoto‐Sugitani;S. Wada;M. Kiyota;S. Mizutani;Y. Chinen;Yosuke Matsumoto;Hisao Nagoshi;Y. Shimura;Tsutomu Kobayashi;S. Horiike;Kenji Sato;M. Taniwaki

Phosphoinositide-dependent protein kinase 1 is a crucial cell signaling mediator in multiple myeloma.

磷酸肌醇依赖性蛋白激酶 1 是多发性骨髓瘤中至关重要的细胞信号传导介质。

• 发表时间: 2014
• 作者: Chinen Y;Kuroda J;Shimura Y;Nagoshi H;Kiyota M;Sugitani M;Mizutani S;Sakamoto N;Ri M;Kawata E;Kobayashi T;Matsumoto Y;Horiike S;Iida S;Taniwaki M.
• 通讯作者: Taniwaki M.