Comprehensive strategy of heart failure, cardiac hypertrophy and lethal arrhythmia via stabilizing the stricture of ryanodine receptor

通过稳定兰尼碱受体狭窄治疗心力衰竭、心肌肥厚和致死性心律失常的综合策略

• 批准号: 26293189
• 负责人: YANO Masafumi
• 金额: $ 10.65万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2014
• 资助国家: 日本
• 起止时间: 2014-04-01 至 2017-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-26293189/
• 关键词: リアノジン受容体; Caハンドリング; カルモジュリン; 筋小胞体; 致死的不整脈; Ca2+ハンドリング; CPVT; リアニジン受容体

项目成果

A low-dose β1-blocker in combination with milrinone improves intracellular Ca2+ handling in failing cardiomyocytes by inhibition of milrinone-induced diastolic Ca2+ leakage from the sarcoplasmic reticulum.

• DOI: 10.1371/journal.pone.0114314
• 发表时间: 2015
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Kobayashi S;Susa T;Ishiguchi H;Myoren T;Murakami W;Kato T;Fukuda M;Hino A;Suetomi T;Ono M;Uchinoumi H;Tateishi H;Mochizuki M;Oda T;Okuda S;Doi M;Yamamoto T;Yano M
• 通讯作者: Yano M

Nuclear Translocation of Calmodulin, Which Dissociated From Cardiac Ryanodine Receptor, Promotes the Pathological Cardiac Hypertrophy

从心脏兰尼丁受体解离的钙调蛋白的核转位促进病理性心脏肥大

• 发表时间: 2016
• 作者: Tetsuro Oda;Takeshi Yamamoto;Takayoshi Kato;Shigehiko Nishimura;Go Fukui;Shinichi Okuda;Shigeki Kobayashi;Donald Bers and Masafumi Yano
• 通讯作者: Donald Bers and Masafumi Yano

Oxidation of ryanodine receptor (RyR) and calmodulin enhance Ca release and pathologically alter, RyR structure and calmodulin affinity.

• DOI: 10.1016/j.yjmcc.2015.06.009
• 发表时间: 2015-08
• 期刊: Journal of molecular and cellular cardiology
• 影响因子: 5
• 作者: Oda T;Yang Y;Uchinoumi H;Thomas DD;Chen-Izu Y;Kato T;Yamamoto T;Yano M;Cornea RL;Bers DM
• 通讯作者: Bers DM

Correction of the Defective Channel Gating of Cardiac Ryanodine Receptor Improves Cardiac Function and Suppresses Ventricular Arrhythmia in Post Myocardial Infarction Heart Failure

纠正心脏兰尼丁受体通道门控缺陷可改善心肌梗死后心力衰竭的心功能并抑制室性心律失常

• 发表时间: 2016
• 作者: Hironori Ishiguchi;Shigeki Kobayashi;Michiaki Kohno;Takuma Nanno;Gou Fukui;Yoko Sufu-Shimizu;Yoriomi Hamada;Takako Maeda;Shigehiko Nishimura;Tetsuro Oda;Shinnichi Okuda;Takeshi Ueyama;Takeshi Yamamoto;Masafumi Yano
• 通讯作者: Masafumi Yano

High Affinity CaM, but Not Normal Affinity CaM Can Prevent Arrhythmias in CPVT Which Mutation is Located at CaM-like Domain of RyR2.

高亲和力CaM而非普通亲和力CaM可以预防CPVT中的心律失常，其突变位于RyR2的CaM样结构域。

• 发表时间: 2015
• 作者: Nishimura S;Yamamoto T;Fukui G;Maeda T;Hino A;Suetomi T;Ono M;Mochozuki M;Oda T;Okuda S;Kobayashi S;Yano M
• 通讯作者: Yano M