An attempt to regress cardiac hypertrophy by cardiomyocyte intracellular calmodulin control
An attempt to regress cardiac hypertrophy by cardiomyocyte intracellular calmodulin control
批准号:
16K15443
负责人:
YANO Masafumi
金额:
$2.25万
依托单位:
依托单位国家:
日本
项目类别:
Grant-in-Aid for Challenging Exploratory Research
财政年份:
2016
资助国家:
日本
项目状态:
已结题
起止时间:
2016-04-01 至 2018-03-31
中文摘要
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英文摘要
期刊论文(20)
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科研奖励(0)
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Channel Pore Mutation of RyR2 Cause Calcium Leak Independent of FKBP12.6-RyR2 and Calmodulin-RyR2 Affinity in R4496C/+ Knock-in Mouse
R4496C/敲入小鼠中 RyR2 的通道孔突变导致钙渗漏,与 FKBP12.6-RyR2 和钙调蛋白-RyR2 亲和力无关
DOI:
--
发表时间:
2017
期刊:
影响因子:
--
作者:
[Hitoshi Uchinoumi, Ivanita Stefanon, Yi Yang, Mena Said, Xiaoqiong Dong, Rogerio Faustino, Jose L Puglisi, Ye Chen-Izu, Razvan L Cornea, Xander H Wehrens, Wayne S Chen, Takeshi Yamamoto, Yano Masafumi and Donald M Bers]
通讯作者:
Yano Masafumi and Donald M Bers
Nuclear Translocation of Calmodulin, Which Dissociated From Cardiac Ryanodine Receptor, Promotes the Pathological Cardiac Hypertrophy
从心脏兰尼丁受体解离的钙调蛋白的核转位促进病理性心脏肥大
DOI:
--
发表时间:
2016
期刊:
影响因子:
--
作者:
[Tetsuro Oda, Takeshi Yamamoto, Takayoshi Kato, Shigehiko Nishimura, Go Fukui, Shinichi Okuda, Shigeki Kobayashi, Donald Bers and Masafumi Yano]
通讯作者:
Donald Bers and Masafumi Yano
Stabilization of Camkii-Phosphorylated Ryr2 by Dantrolene Prevents the Development of Age-Related Cardiomyopathy Caused by CamkiiδC Overexpression
Dantrolene 对 Camkii 磷酸化 Ryr2 的稳定可预防由 CamkiiδC 过度表达引起的年龄相关性心肌病的发展
DOI:
--
发表时间:
2017
期刊:
影响因子:
--
作者:
[Yoko S Shimizu, Shinichi Okuda, Yoko Okamoto, Shigehiko Nishimura, Takayoshi Kato, Tetsuro Oda, Shigeki Kobayashi, Takeshi Yamamoto and Masafumi Yano]
通讯作者:
Takeshi Yamamoto and Masafumi Yano
Effect of Site Dependent RyR Stabilizers; a Clue to Trace a Signal Transmission Pathway Inside the RyR Molecule
位点依赖性 RyR 稳定剂的效果;
DOI:
--
发表时间:
2017
期刊:
影响因子:
--
作者:
[Go Fukui, Takeshi Yamamoto, Michiaki Kono, Yoshihide Nakamura, Takuma Nanno, Yoriomi Hamada, Yoko Sufu, Hironori Ishiguchi, Shigehiko Nishimura, Hitoshi Uchinoumi, Tetsuro Oda, Shinichi Okuda, Shigeki Kobayashi and Masafumi Yano]
通讯作者:
Shigeki Kobayashi and Masafumi Yano
DOI:
10.1371/journal.pone.0163250
发表时间:
2016
期刊:
PloS one
影响因子:
3.7
作者:
[Murakami W, Kobayashi S, Susa T, Nanno T, Ishiguchi H, Myoren T, Nishimura S, Kato T, Hino A, Oda T, Okuda S, Yamamoto T, Yano M]
通讯作者:
Yano M
共 13 条
Comprehensive treatment of heart failure, cardiac hypertrophy, and arrhythmia by controlling ryanodine receptor bound calmodulin
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批准号:17H04178
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项目类别:Grant-in-Aid for Scientific Research (B)
-
资助金额:$10.73万
-
财政年份:2017
-
负责人:YANO Masafumi
-
依托单位:
New molecular targeting therapy for regression of cardiac hypertrophy by inhibiting abnormal Ca2+ leak through RyR2 in hypertrophic cardiomyopathy
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批准号:26670404
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项目类别:Grant-in-Aid for Challenging Exploratory Research
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资助金额:$2.33万
-
财政年份:2014
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负责人:YANO Masafumi
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依托单位:
Comprehensive strategy of heart failure, cardiac hypertrophy and lethal arrhythmia via stabilizing the stricture of ryanodine receptor
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批准号:26293189
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$10.65万
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财政年份:2014
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负责人:YANO Masafumi
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依托单位:
Development of comprehensive treatment of heart failure, hypertrophy, and arrhythmia by regulating intracellular Ca
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批准号:23390215
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.31万
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财政年份:2011
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负责人:YANO Masafumi
-
依托单位:
Development of therapeutic therapy for regression of cardiac hypertrophy in hypertrophic cardiomyopathy
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批准号:22659154
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项目类别:Grant-in-Aid for Challenging Exploratory Research
-
资助金额:$2.02万
-
财政年份:2010
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负责人:YANO Masafumi
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依托单位:
Development of new therapy for heart failure and arrhythmia by correction of signal transduction within cardiac ryanodine receptor
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批准号:20390226
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$12.15万
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财政年份:2008
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负责人:YANO Masafumi
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依托单位:
Establishment of molecular targeting therapy for duonic heart failure bystabilizmgryanodine receptor
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批准号:18390234
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项目类别:Grant-in-Aid for Scientific Research (B)
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资助金额:$9.96万
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财政年份:2006
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负责人:YANO Masafumi
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依托单位:
Computational study on acoustic-image perception of object-shape from single-emission echo in bats
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批准号:17500190
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.24万
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财政年份:2005
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负责人:YANO Masafumi
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依托单位:
Research in the inhibitory effect of sarcoplasmic reticulum Ca release channel stabilizer on the development of heart failure
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批准号:13670717
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.56万
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财政年份:2001
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负责人:YANO Masafumi
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依托单位:
Assessment of cardiac excitation-contraction coupling and effect of positive inctropic agent on Ca^<2+> regulating function of sarcoplasmic reticulum in heart failan
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批准号:11670684
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项目类别:Grant-in-Aid for Scientific Research (C)
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资助金额:$2.3万
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财政年份:1999
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负责人:YANO Masafumi
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依托单位:
Self-Organization of Polymorphic Circuits in Cultured Neural Networks
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批准号:06454660
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.14万
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财政年份:1994
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负责人:YANO Masafumi
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依托单位:
Reconstruction of the Module Structure of Cerebellum in Vitro
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批准号:01480535
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项目类别:Grant-in-Aid for General Scientific Research (B)
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资助金额:$3.46万
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财政年份:1989
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负责人:YANO Masafumi
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依托单位:
海外基金