An attempt to regress cardiac hypertrophy by cardiomyocyte intracellular calmodulin control

通过心肌细胞内钙调蛋白控制来逆转心脏肥大的尝试

• 批准号: 16K15443
• 负责人: YANO Masafumi
• 金额: $ 2.25万
• 依托单位: Yamaguchi University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Challenging Exploratory Research
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/en/grant/KAKENHI-PROJECT-16K15443/
• 关键词: リアノジン受容体; カルモジュリン; 心肥大; EC coupling; 心不全; 不整脈

项目成果

Channel Pore Mutation of RyR2 Cause Calcium Leak Independent of FKBP12.6-RyR2 and Calmodulin-RyR2 Affinity in R4496C/+ Knock-in Mouse

R4496C/敲入小鼠中 RyR2 的通道孔突变导致钙渗漏，与 FKBP12.6-RyR2 和钙调蛋白-RyR2 亲和力无关

• 发表时间: 2017
• 作者: Hitoshi Uchinoumi;Ivanita Stefanon;Yi Yang;Mena Said;Xiaoqiong Dong;Rogerio Faustino;Jose L Puglisi;Ye Chen-Izu;Razvan L Cornea;Xander H Wehrens;Wayne S Chen;Takeshi Yamamoto;Yano Masafumi and Donald M Bers
• 通讯作者: Yano Masafumi and Donald M Bers

Nuclear Translocation of Calmodulin, Which Dissociated From Cardiac Ryanodine Receptor, Promotes the Pathological Cardiac Hypertrophy

从心脏兰尼丁受体解离的钙调蛋白的核转位促进病理性心脏肥大

• 发表时间: 2016
• 作者: Tetsuro Oda;Takeshi Yamamoto;Takayoshi Kato;Shigehiko Nishimura;Go Fukui;Shinichi Okuda;Shigeki Kobayashi;Donald Bers and Masafumi Yano
• 通讯作者: Donald Bers and Masafumi Yano

Stabilization of Camkii-Phosphorylated Ryr2 by Dantrolene Prevents the Development of Age-Related Cardiomyopathy Caused by CamkiiδC Overexpression

Dantrolene 对 Camkii 磷酸化 Ryr2 的稳定可预防由 CamkiiδC 过度表达引起的年龄相关性心肌病的发展

• 发表时间: 2017
• 作者: Yoko S Shimizu;Shinichi Okuda;Yoko Okamoto;Shigehiko Nishimura;Takayoshi Kato;Tetsuro Oda;Shigeki Kobayashi;Takeshi Yamamoto and Masafumi Yano
• 通讯作者: Takeshi Yamamoto and Masafumi Yano

Effect of Site Dependent RyR Stabilizers; a Clue to Trace a Signal Transmission Pathway Inside the RyR Molecule

位点依赖性 RyR 稳定剂的效果；

• 发表时间: 2017
• 作者: Go Fukui;Takeshi Yamamoto;Michiaki Kono;Yoshihide Nakamura;Takuma Nanno;Yoriomi Hamada;Yoko Sufu;Hironori Ishiguchi;Shigehiko Nishimura;Hitoshi Uchinoumi;Tetsuro Oda;Shinichi Okuda;Shigeki Kobayashi and Masafumi Yano
• 通讯作者: Shigeki Kobayashi and Masafumi Yano

Recombinant Atrial Natriuretic Peptide Prevents Aberrant Ca2+ Leakage through the Ryanodine Receptor by Suppressing Mitochondrial Reactive Oxygen Species Production Induced by Isoproterenol in Failing Cardiomyocytes.

• DOI: 10.1371/journal.pone.0163250
• 发表时间: 2016
• 期刊: PloS one
• 影响因子: 3.7
• 作者: Murakami W;Kobayashi S;Susa T;Nanno T;Ishiguchi H;Myoren T;Nishimura S;Kato T;Hino A;Oda T;Okuda S;Yamamoto T;Yano M
• 通讯作者: Yano M