Integrating multiple omics analysis for understanding the pathological mechanism of chronic hepatitis B virus infection and identifying potential molecular targets using humanized chimeric mice

整合多组学分析以了解慢性乙型肝炎病毒感染的病理机制并利用人源化嵌合小鼠识别潜在的分子靶点

• 批准号: 15K06810
• 负责人: TSUBOTA Akihito
• 金额: $ 3.24万
• 依托单位: Jikei University School of Medicine
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15K06810/
• 关键词: B型肝炎; B型肝炎ウイルス; ヒト化肝臓キメラマウス; トランスクリプトーム解析

项目成果

Hepatocellular adenoma in a woman who was undergoing testosterone treatment for gender identity disorder

一名因性别认同障碍而接受睾酮治疗的女性的肝细胞腺瘤

• DOI: 10.1007/s12328-018-0854-4
• 发表时间: 2018
• 期刊: Clin J Gastroenterol
• 影响因子: 1
• 作者: Kato K;Abe H;Hanawa N;Fukuzawa J;Matsuo R;Yonezawa T;Itoh S;Sato Y;Ika M;Shimizu S;Endo S;Hano H;Izu A;Sugitani M;Tsubota A
• 通讯作者: Tsubota A

Vitamin D-related gene polymorphisms do not influence the outcome and serum vitamin D level in pegylated interferon/ribavirin therapy combined with protease inhibitor for patients with genotype 1b chronic hepatitis C.

维生素D相关基因多态性不影响聚乙二醇干扰素/利巴韦林联合蛋白酶抑制剂治疗基因1b型慢性丙型肝炎患者的结局和血清维生素D水平。

• DOI: 10.1002/jmv.24244
• 发表时间: 2015
• 期刊: J Med Virol
• 影响因子: 12.7
• 作者: Arai T;Atsukawa M;Tsubota A;Kondo C;Shimada N;Abe H;Itokawa N;Nakagawa A;Okubo T;Aizawa Y;Iwakiri K.
• 通讯作者: Iwakiri K.

A novel device for estimating olfactory threshold for differential diagnosis of parkinsonian syndrome: a pilot study

一种用于估计嗅阈以鉴别诊断帕金森综合征的新型装置：一项试点研究

• 发表时间: 2017
• 作者: Omoto S;Mori E;Fujioka K;Tsubota A;Kita J;Kinoshita M;Matsuno H;Sakai K;Toyoda C;Iguchi Y
• 通讯作者: Iguchi Y

Influencing factors on serum 25-hydroxyvitamin D3 levels in Japanese chronic hepatitis C patients.

• DOI: 10.1186/s12879-015-1020-y
• 发表时间: 2015-08-19
• 期刊: BMC infectious diseases
• 影响因子: 3.7
• 作者: Atsukawa M;Tsubota A;Shimada N;Yoshizawa K;Abe H;Asano T;Ohkubo Y;Araki M;Ikegami T;Kondo C;Itokawa N;Nakagawa A;Arai T;Matsushita Y;Nakatsuka K;Furihata T;Chuganji Y;Matsuzaki Y;Aizawa Y;Iwakiri K
• 通讯作者: Iwakiri K

Effectiveness and safety of community-based treatment with sofosbuvir plus ribavirin for elderly patients with genotype 2 chronic hepatitis C

• DOI: 10.1016/j.dld.2017.04.012
• 发表时间: 2017-09-01
• 期刊: DIGESTIVE AND LIVER DISEASE
• 影响因子: 4.5
• 作者: Atsukawa, Masanori;Tsubota, Akihito;Iwakiri, Katsuhiko
• 通讯作者: Iwakiri, Katsuhiko