重症ＲＳウイルス患者における危険因子および分子遺伝子型研究

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To investigate the clinical relevance of RSV-A ON1,acute respiratory infection (ARI) cases enrolled to our population-based prospective pediatric ARI surveillance at Khanh Hoa General Hospital, Central Vietnam from January 2010 through December 2012 were studied. Clinical-epidemiological information and nasopharyngeal samples were collected. Multiplex PCR assays were performed for screening 13 respiratory viruses. RSVpositive samples were further tested for subgroups (A/B) and genotypes information by sequencing the G-glycoprotein 2nd hypervariable region. Statistical analysis was performed to evaluate the clinicalepidemiological characteristics of RSV-A ON1. The study demonstrated the clinical relevance of RSV-A ON1 infected ARI cases. Respiratory viruses were detected in 66.2% of the cases, in which RSV (n = 426, 23.0%), Influenza (12.0%) and Rhinovirus (25.1%) were the leading respiratory viruses detected. RSV-positive cases were significantly younger, wheezing (52.8%), tachypnea (31.0%), crackle (21.6%) and chest-wall indrawing (9.9%) were significantly more common. In this study, 123 RSV-A ON1 and 138 NA1 were genotyped. ON1 cases were younger, frequently associated with underlying medical condition and respiratory sign and symptoms such as wheeze (81.3%), tachypnea (50.4%) and difficulty in breathing (18.7%). In addition, ARI cases with LRTI (34.2%) and radiologically-confirmed pneumonia (19.5%) were more commonly seen in ON1 ARI cases.