Elucidation of molecular mechanism for pancreato-biliary cancer progression through EMT plasticity

通过 EMT 可塑性阐明胰胆管癌进展的分子机制

• 批准号: 15H04925
• 负责人: Takano Shigetsugu
• 金额: $ 11.15万
• 依托单位: Chiba University
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (B)
• 财政年份: 2015
• 资助国家: 日本
• 起止时间: 2015-04-01 至 2018-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-15H04925/
• 关键词: 膵癌; Prrx1; Metadherin; 中和抗体; Epithelial plasticity; EMT; MET; 転移; 膵臓外科学; 浸潤・転移; 浸潤、転移

项目成果

Immune-complex level of cofilin-1 in sera is associated with cancer progression and poor prognosis in pancreatic cancer.

• DOI: 10.1111/cas.13181
• 发表时间: 2017-04
• 期刊: Cancer science
• 影响因子: 5.7
• 作者: Satoh M;Takano S;Sogawa K;Noda K;Yoshitomi H;Ishibashi M;Mogushi K;Takizawa H;Otsuka M;Shimizu H;Miyazaki M;Nomura F
• 通讯作者: Nomura F

ETV5 regulates ductal morphogenesis with Sox9 and is critical for regeneration from pancreatitis.

• DOI: 10.1002/dvdy.24626
• 发表时间: 2018-06
• 期刊: Developmental dynamics : an official publication of the American Association of Anatomists
• 作者: Das KK;Heeg S;Pitarresi JR;Reichert M;Bakir B;Takano S;Kopp JL;Wahl-Feuerstein A;Hicks P;Sander M;Rustgi AK
• 通讯作者: Rustgi AK

ETS-Transcription Factor ETV1 Regulates Stromal Expansion and Metastasis in Pancreatic Cancer.

• DOI: 10.1053/j.gastro.2016.06.005
• 发表时间: 2016-09
• 期刊: Gastroenterology
• 影响因子: 29.4
• 作者: Heeg S;Das KK;Reichert M;Bakir B;Takano S;Caspers J;Aiello NM;Wu K;Neesse A;Maitra A;Iacobuzio-Donahue CA;Hicks P;Rustgi AK
• 通讯作者: Rustgi AK

Identification of a novel serum biomarker for pancreatic cancer, C4b-binding protein α-chain (C4BPA) by quantitative proteomic analysis using tandem mass tags.

• DOI: 10.1038/bjc.2016.295
• 发表时间: 2016-10-11
• 期刊: BRITISH JOURNAL OF CANCER
• 影响因子: 8.8
• 作者: Sogawa, Kazuyuki;Takano, Shigetsugu;Iida, Fumie;Satoh, Mamoru;Tsuchida, Sachio;Kawashima, Yusuke;Yoshitomi, Hideyuki;Sanda, Akihiro;Kodera, Yoshio;Takizawa, Hirotaka;Mikata, Rintaro;Ohtsuka, Masayuki;Shimizu, Hiroaki;Miyazaki, Masaru;Yokosuka, Osamu;Nomura, Fumio
• 通讯作者: Nomura, Fumio

Identification of a novel serum biomarker for pancreatic cancer, C4b-binding protein alpha-chain (C4BPA) by quantitative proteomic analysis using tandem mass tag

使用串联质量标签进行定量蛋白质组学分析，鉴定胰腺癌的新型血清生物标志物 C4b 结合蛋白 α 链 (C4BPA)

• 发表时间: 2017
• 作者: 高野重紹;曽川一幸;吉富秀幸;清水宏明;古川勝規;高屋敷 吏;久保木 知;鈴木大亮;酒井 望;賀川真吾;野島広之;野村文夫;宮崎 勝;大塚将之
• 通讯作者: 大塚将之