Immunological approach to Th2-dominant tumor microenvironment in malignant lymphoma and new therapeutic strategies

恶性淋巴瘤中Th2为主的肿瘤微环境的免疫学方法和新的治疗策略

• 批准号: 16K10146
• 负责人: SUGAYA MAKOTO
• 金额: $ 3万
• 依托单位: International University of Health and Welfare
• 依托单位国家: 日本
• 项目类别: Grant-in-Aid for Scientific Research (C)
• 财政年份: 2016
• 资助国家: 日本
• 起止时间: 2016-04-01 至 2019-03-31
• 项目状态: 已结题
• 来源: https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16K10146/
• 关键词: 皮膚リンパ腫; 腫瘍微小環境; TSLP; ペリオスチン; CD137L; CD155; CD226; 制御性B細胞; GATA6; HMGB1; プログラニュリン; IL-25; IL-19; IL-36; 可溶性CD48; VEGF; PlGF; 皮膚悪性リンパ腫; ぺリオスチン; Th2サイトカイン; STAT5; 腫瘍免疫; リンパ腫; Th2; TARC

项目成果

IRF-2 haploinsufficiency causes enhanced imiquimod-induced psoriasis-like skin inflammation.

• DOI: 10.1016/j.jdermsci.2017.12.014
• 发表时间: 2017-12
• 期刊: Journal of dermatological science
• 影响因子: 4.6
• 作者: M. Kawaguchi;T. Oka;M. Sugaya;H. Suga;Takayuki Kimura;S. Morimura;H. Fujita;S. Sato

Serum soluble CD48 levels as a prognostic marker in mycosis fungoides and Sézary syndrome.

血清可溶性 CD48 水平作为蕈样肉芽肿和 S 的预后标志物

• DOI: 10.1016/j.jid.2018.03.1519
• 发表时间: 2018
• 期刊: J Invest Dermatol
• 影响因子: 6.5
• 作者: Oka T;Miyagaki T;Takahashi N;Nakajima R;Kamijo H;Suga H;Asano Y;Sugaya M;Sato S.
• 通讯作者: Sato S.

Histone deacetylase inhibitors inhibit metastasis by restoring a tumor suppressive microRNA-150 in advanced cutaneous T-cell lymphoma.

• DOI: 10.18632/oncotarget.13810
• 发表时间: 2017-01-31
• 期刊: Oncotarget
• 作者: Abe F;Kitadate A;Ikeda S;Yamashita J;Nakanishi H;Takahashi N;Asaka C;Teshima K;Miyagaki T;Sugaya M;Tagawa H
• 通讯作者: Tagawa H

Decreased progranulin expression in Mycosis fungoides: a possible association with the high frequency of skin infections

• DOI: 10.1684/ejd.2018.3452
• 发表时间: 2018-11-01
• 期刊: EUROPEAN JOURNAL OF DERMATOLOGY
• 影响因子: 2.5
• 作者: Nakajima, Rina;Miyagaki, Tomomitsu;Sato, Shinichi
• 通讯作者: Sato, Shinichi

Decreased IL-10-producing regulatory B cells in patients with advanced mycosis fungoides

• DOI: 10.1684/ejd.2018.3319
• 发表时间: 2018-05-01
• 期刊: EUROPEAN JOURNAL OF DERMATOLOGY
• 影响因子: 2.5
• 作者: Akatsuka, Taro;Miyagaki, Tomomitsu;Sato, Shinichi
• 通讯作者: Sato, Shinichi