Novel Strategy for the Total Synthesis of Macrocyclic Natural Products

在抗真菌剂15G256ß的合成中，建立了一种大环天然产物全合成的新策略。这包括在非常温和的条件下通过聚羰基化合物的环化来仿生合成芳烃，以及构建大内酯。这一策略将为许多具有6-烷基-2,4-二羟基苯甲酸单位的大环生物活性天然产物提供新的途径。此外，还建议了两条通往15G256ß关键构件的独立路线。

A novel strategy for the total synthesis of macrocyclic natural products will be established in the synthesis of antifungal agent 15G256ß. This includes the biomimetic synthesis of arenes by cyclisation of polycarbonyl compounds under very mild conditions as well as the construction of a macrolactone. This strategy will allow a new approach to numerous macrocyclic bioactive natural products bearing the 6-alkyl-2,4-dihydroxybenzoic unit. Furthermore two independent routes to the key building blocks for 15G256ß are suggested.