Novel Strategy for the Total Synthesis of Macrocyclic Natural Products

大环天然产物全合成新策略

• 批准号: 5442818
• 负责人: Professor Dr. Thomas Werner
• 金额: --
• 依托单位: Department of Chemistry
• 依托单位国家: 德国
• 项目类别: Research Fellowships
• 财政年份: 2004
• 资助国家: 德国
• 起止时间: 2003-12-31 至 2005-12-31
• 项目状态: 已结题
• 来源: https://gepris.dfg.de/gepris/projekt/5442818?language=en
• 关键词: Novel; Strategy; Total; Synthesis; Macrocyclic

A novel strategy for the total synthesis of macrocyclic natural products will be established in the synthesis of antifungal agent 15G256ß. This includes the biomimetic synthesis of arenes by cyclisation of polycarbonyl compounds under very mild conditions as well as the construction of a macrolactone. This strategy will allow a new approach to numerous macrocyclic bioactive natural products bearing the 6-alkyl-2,4-dihydroxybenzoic unit. Furthermore two independent routes to the key building blocks for 15G256ß are suggested.

在抗真菌药物15 G256的合成中，为大环天然产物的全合成提供了一种新的策略。这包括在非常温和的条件下通过多羰基化合物的环化来仿生合成芳烃以及构建大环内酯。这种策略将允许一种新的方法，许多大环生物活性天然产品轴承6-烷基-2，4-二羟基苯甲酸单位。此外，两个独立的路线，15 G256的关键构件的建议。