マイクロ流体過程を用いた効果的なクルクミン送達のためのポリエステルナノ粒子の合成

使用微流体工艺合成聚酯纳米颗粒以有效递送姜黄素

基本信息

批准号：
16F16720
负责人：
SHEN Amy
金额：
$ 0.77万
依托单位：
Okinawa Institute of Science and Technology Graduate University
依托单位国家：
日本
项目类别：
Grant-in-Aid for JSPS Fellows
财政年份：
2016
资助国家：
日本
起止时间：
2016-07-27 至 2017-03-31
项目状态：
已结题

来源：
https://kaken.nii.ac.jp/grant/KAKENHI-PROJECT-16F16720/
关键词：
Microfluidics Nanoprecipitation Nanoparticles Dynamic light scattering Curcumin Drug delivery

项目摘要

The proposed research goals are completed smoothly as expected. Microfluidic devices for curcumin-polyester nanoparticle (Cur-PE-NPs) synthesis has been fabricated successfully. The synthesis of nanoparticle inside microfluidics devices was captured with confocal fluorescence microscope. The synthesized Cur-PE NPs were characterized with dynamic light scattering and target particle size distributions were achieved with the optimized devices. The average particle sizes are less than 100 nm with a polydispersity index of less than 0.2, which indicate the fabricated microfluidic devices provide a controlled environment for the formation of Cur-PE NPs. These results confirm that microfluidic devices are excellent tools in the development of novel polyester nanoparticles for drug delivery. In addition to the physical characterization of the synthesized Cur-PE NPs, its degradation kinetics in solution was investigated using UV-vis spectroscopy. The results indicated that these Cur-PE NPs are stable for days. Furthermore, the encapsulated curcumin molecules are significantly solubilized and stabilized in an aqueous environment. This research has demonstrated that microfluidic devices are unique platforms in the development of novel polyester nanoparticles for drug delivery. Our results suggest that the microfluidic synthesized Cur-PE NP have potential as drug carrier for curcumin. These results have been presented in international symposium and conference and a manuscript is currently in preparation for publication in an international peer-reviewed journal.

拟议的研究目标按预期顺利完成。姜黄素 - 多溶性纳米颗粒（Cur-PE-NP）合成的微流体设备已成功制造。用共聚焦荧光显微镜捕获了微流体内部装置内部纳米颗粒的合成。通过动态光散射表征合成的Cur-PE NP，并使用优化的设备实现目标粒径分布。平均粒径小于100 nm，多分散指数小于0.2，这表明制造的微流体设备为形成Cur-PE NP的形成提供了一个控制的环境。这些结果证实，微流体设备是开发用于药物输送的新型聚酯纳米颗粒的出色工具。除了合成的Cur-PE NP的物理表征外，还使用UV-VIS光谱研究了其在溶液中的降解动力学。结果表明这些Cur-PE NP稳定了几天。此外，封装的姜黄素分子在水性环境中显着溶解并稳定。这项研究表明，微流体设备是用于药物输送的新型聚酯纳米颗粒开发的独特平台。我们的结果表明，微流体合成的Cur-PE NP具有姜黄素药物载体的潜力。这些结果已在国际研讨会和会议上提出，目前正在准备在国际同行评审期刊上出版的手稿。